51925-56-5

Basic information

• Product Name: ethyl 3-(2-ethoxy-2-oxoethylaMino)-3-oxopropanoate
• Synonyms: ethyl 3-(2-ethoxy-2-oxoethylaMino)-3-oxopropanoate
• CAS NO: 51925-56-5
• Molecular Formula: C9H15NO5
• Molecular Weight: 217.2191
• Mol File: 51925-56-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 350.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.143±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.39±0.46(Predicted)
• CAS DataBase Reference: ethyl 3-(2-ethoxy-2-oxoethylaMino)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(2-ethoxy-2-oxoethylaMino)-3-oxopropanoate(51925-56-5)
• EPA Substance Registry System: ethyl 3-(2-ethoxy-2-oxoethylaMino)-3-oxopropanoate(51925-56-5)

Safety Data

• Hazardous Substances Data: 51925-56-5(Hazardous Substances Data)

Usage

General Description

Ethyl 3-(2-ethoxy-2-oxoethylamino)-3-oxopropanoate is a chemical compound with the molecular formula C10H17NO5. It is a derivative of the amino acid glycine and is commonly used in the synthesis of pharmaceuticals and organic compounds. ethyl 3-(2-ethoxy-2-oxoethylaMino)-3-oxopropanoate is a white to off-white crystalline powder with a molecular weight of 231.247 g/mol. It is soluble in water and polar organic solvents and has a wide range of uses in various industries including the pharmaceutical, cosmetic, and food industries. The compound is important in the production of drugs and biologically active molecules due to its properties and potential applications in medicinal chemistry.

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 105-53-3 diethyl malonate 
• 1071-46-1 hydrogen ethyl malonate 
• 55552-69-7 2-ethylmalonyl dichloride 
• 6148-64-7 ethyl potassium malonate 

Downstream Products

• 37772-85-3 methyl 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 

Relevant articles and documents

Structure-activity relationship study of 3-amino-2-indolyllactam derivatives: Development of inhibitors of oxidative stress-induced necrosis

Modification of our previously reported selective inhibitor of oxidative stress-induced necrosis, 2-(1H-indol-3-yl)-3-pentylamino-maleimide (IM-54) by regioselective reduction of the C-4 carbonyl group afforded a 3-amino-2-indolyllactam (IL-1) with more potent activity. To examine the structure-activity relationship of IL derivatives, we developed new synthetic routes with flexibility to incorporate a range of substituents at a late stage. The synthesized IL derivatives were evaluated for activity to inhibit necrotic cell death induced by hydrogen peroxide. Among them, IL-12 showed the most potent activity (IC50=49 nM) among the IL and indolylmaleimide (IM) derivatives examined.

Studies on the synthesis and bioactivities of 4-amino derivatives of tetramic acid

In order to study the potential bioactivities of 4-amino tetramic acid derivatives, the 4-amination products of pyrrolidine-2,4-diones (5) and 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylates (4) were prepared. The 4-amination of 5 took place in high yield when catalyzed by acetic acid, whereas the 4-amination of 4 was achieved through a 4-ethoxy intermediate, which was prepared by acidic etherification. Their herbicidal, fungicidal, insecticidal, and antitumor activities were tested. The bioassays showed that two of the compounds exhibited good herbicidal activity against dicot Arabidopsis thaliana at a concentration of 10 μg/mL, and one compound gave instinct fungicidal activity against Pythium sp. at a concentration of 2 μg/mL.

Tetramic acids as scaffolds: Synthesis, tautomeric and antibacterial behaviour

Efficient synthetic routes for tetramic acids variously substituted on the ring nitrogen, their tautomeric behaviour in solution and their antibiotic activity are reported.