51941-58-3

Upstream product

• 51941-57-2 1,2-Dimethyl-2-hydroxymethyl-1-p-tolylcyclopentane 
• 5453-88-3 ethyl 1-methyl-2-oxocyclopentane-1-carboxylate 
• 51941-56-1 2-Carbethoxy-1,2-dimethyl-1-p-tolylcyclopentane 
• 51941-54-9 2-Carbethoxy-2-methyl-p-tolylcyclopent-1-ene 
• 51941-55-0 1-Bromo-2-carbethoxy-2-methyl-1-p-tolylcyclopentane 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 51941-57-2 (1R^*,2S^*)-1,2-Dimethyl-2-(4-methylphenyl)cyclopentanemethanol 
• 1821-23-4 1-cyclohex-1-enyl-4-methylbenzene 
• 100847-96-9 5-(p-toluoyl)valeric acid 
• 117421-36-0 6-oxo-6-(p-tolyl)hexanal 
• 100847-92-5 ethyl 5-methyl-p-tolylcyclopent-1-ene-1-carboxylate 
• 100847-87-8 ethyl 6-oxo-6-p-tolylhexanoate 
• 51941-56-1 ethyl cis-1,2-dimethyl-2-(4-methylphenyl)cyclopentanecarboxylate 
• 100847-88-9 ethyl 6-hydroxy-6-p-tolylheptanoate 

Downstream Products

• 16982-00-6 1-(1,2,2-trimethylcyclopentyl)-4-methylbenzene 
• 16982-00-6 cuparene 
• 56324-31-3 (S)-1-methyl-4-(1,2,2-trimethylcyclopentyl)benzene 

Relevant academic research and scientific papers

Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction

Oxidative ring contraction of cyclic α-formyl ketones was facilitated by the action of H2O2under operationally simple and environmentally benign reaction conditions. The process was highly regioselective and enables stereospecific construction of contiguous quaternary all-carbon centers from stereodefined all-substituted all-cyclic ketones. The asymmetric syntheses of (+)-cuparene and (+)-tochuinyl acetate were also successively achieved by taking advantage of this novel protocol.

SYNTHESIS OF AROMATIC SESQUITERPENES, (+/-)-CUPARENE AND (+/-)-LAURENE BY MEANS OF AN INTRAMOLECULAR CARBENOID DISPLACEMENT (ICD) REACTION

The synthesis of (+/-)-cuparene and (+/-)-laurene was accomplished by means of an intramolecular carbenoid displacement (ICD) reaction of the benzyl sulphide (12) as a key reaction.

Synthesis of an Aromatic Sesquiterpene, (+/-)-Cuparene, via Construction of a Quaternary Carbon Centre by an Intramolecular Carbenoid Displacement Reaction

The synthesis of (+/-)-cuparene (11), which includes as the key step an intramolecular carbenoid displacement reaction at the benzylic position of a benzyl sulphide derivative, is described.