5202-83-5Relevant academic research and scientific papers
Nickel-Catalyzed Asymmetric Synthesis of α-Arylbenzamides
Cuesta-Galisteo, Sergio,Sch?rgenhumer, Johannes,Wei, Xiaofeng,Merino, Estíbaliz,Nevado, Cristina
supporting information, p. 1605 - 1609 (2020/12/01)
A nickel-catalyzed asymmetric reductive hydroarylation of vinyl amides to produce enantioenriched α-arylbenzamides is reported. The use of a chiral bisimidazoline (BIm) ligand, in combination with diethoxymethylsilane and aryl halides, enables the regioselective introduction of aryl groups to the internal position of the olefin, forging a new stereogenic center α to the N atom. The use of neutral reagents and mild reaction conditions provides simple access to pharmacologically relevant motifs present in anticancer, SARS-CoV PLpro inhibitors, and KCNQ channel openers.
Br?nsted acid catalyzed proto-functionalization of enecarbamates and enamides: A convenient route to N,O-acetals
Chang-Fei, Zhang,Wei, Zou,Xiao-Yan, Ma,Xinjun, Hu,Yanli, Li
supporting information, (2020/04/01)
N,O-acetals are important structures found in many bioactive natural products, and this unique organic functional group can serve as a useful synthetic precursor to the unstable N-acylimines. In this paper, a convenient route to synthesize N-carbamoyl-N,O
