13313-25-2Relevant articles and documents
Facile Preparation of N-Vinylisobutyramide and N-Vinyl-2-pyrrolidinone
Tu, Siyu,Zhang, Chunming
, p. 2045 - 2049 (2015)
A facile synthesis of N-vinylakylamides from commercially available N-vinylformamide and corresponding acyl chlorides was developed and exemplified by the preparation of N-vinylisobutyramide (NVIBA) and N-vinyl-2-pyrrolidinone (NVP) in high yields (80-89%). Both NVIBA and NVP are valuable monomers for water-soluble polymers with an array of applications in personal care, pharmaceutical, agricultural, and industrial products.
Catalytic Strategy for Regioselective Arylethylamine Synthesis
Boyington, Allyson J.,Seath, Ciaran P.,Zearfoss, Avery M.,Xu, Zihao,Jui, Nathan T.
supporting information, p. 4147 - 4153 (2019/03/07)
A mild, modular, and practical catalytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported. Using a unique combination of organic catalysts to promote the transfer of electrons and hydrogen atoms, this system performs direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol. The utility of this process is highlighted by its scalability and the modular synthesis of an array of bioactive small molecules.
A convenient synthesis of N-vinyl enamides via the lithiation and ring-opening reaction of 2-phenyl-2-oxazolines
Xu, Yi,Liu, Xiao-Yu,Wang, Zi-Qi,Tang, Liang-Fu
, p. 1788 - 1791 (2017/04/13)
A simple and efficient synthesis of N-vinyl enamides via the lithiation and ring-opening reaction of 2-phenyl-2-oxazolines with lithium diisopropylamide at room temperature has been developed. This method is especially suitable for the synthesis of multif
