52026-99-0

Basic information

• Product Name: Pyridine, 3,4-dichloro-2,5,6-trifluoro-
• Synonyms: 3,4-Dichloro-2,5,6-trifluoropyridine
• CAS NO: 52026-99-0
• Molecular Formula: C₅Cl₂F₃N
• Molecular Weight: 201.96
• Mol File: 52026-99-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 3,4-dichloro-2,5,6-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3,4-dichloro-2,5,6-trifluoro-(52026-99-0)
• EPA Substance Registry System: Pyridine, 3,4-dichloro-2,5,6-trifluoro-(52026-99-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 52026-99-0(Hazardous Substances Data)

Upstream product

• 700-16-3 Pentafluoropyridine 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 14336-71-1 calcium chloride 

Relevant articles and documents

SNAr catalysis enhanced by an aromatic donor-acceptor interaction; Facile access to chlorinated polyfluoroarenes

Selective catalytic SNAr reaction of polyfluoroaryl C-F bonds with chloride is shown. Stoichiometric TMSCl makes the reaction exergonic and allows catalysis, which involves ground state elevation of chloride, aromatic donor-acceptor interactions, and stabilization of the Meisenheimer complex. Traditional cross-coupling of the products is now possible and demonstrates the utility.