3,4-Dichloro-2,5,6-trifluoropyridine

Base Information

• Chemical Name: 3,4-Dichloro-2,5,6-trifluoropyridine
• CAS No.: 52026-99-0
• Molecular Formula: C5Cl2F3N
• Molecular Weight: 201.963
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20556650
• Wikidata: Q82438283
• Mol file: 52026-99-0.mol

Synonyms:3,4-DICHLORO-2,5,6-TRIFLUOROPYRIDINE;52026-99-0;2,3,6-trifluorodichloropyridine;SCHEMBL10744284;DTXSID20556650;MFCD12024847;AKOS005256362

Chemical Property of 3,4-Dichloro-2,5,6-trifluoropyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.80570
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 200.9359889
• Heavy Atom Count: 11
• Complexity: 148

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dichloro-2,5,6-trifluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=C(C(=C(N=C1F)F)Cl)Cl)F

Technology Process of 3,4-Dichloro-2,5,6-trifluoropyridine

There total 7 articles about 3,4-Dichloro-2,5,6-trifluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-chloro-2,4,5,6-tetrafluoropyridine (1735-84-8) + calcium chloride (14336-71-1) → 3,4-dichloro-2,5,6-trifluoropyridinev (52026-99-0)

Guidance literature:

In sulfolane; molar ratio ClC5F4N/CaCl2 = 1/7.5; heating in vacuum (5 Torr) until 100 ml solvent are distilled off; addition of ethyleneglycol and heating to 210 °C (15 min);;

Reference yield: 72.0%

3-chloro-2,4,5,6-tetrafluoropyridine (1735-84-8) → 3,4-dichloro-2,5,6-trifluoropyridinev (52026-99-0)

Guidance literature:

With chloro-trimethyl-silane; benzyltri(n-butyl)ammonium chloride; In tetrahydrofuran; at 80 ℃; Sealed tube;

DOI:10.1039/c7cc03996d

Reference yield: 60.0%

3-chloro-2,4,5,6-tetrafluoropyridine (1735-84-8) + calcium chloride (14336-71-1) → 3,4-dichloro-2,5,6-trifluoropyridinev (52026-99-0) + 3,4,6-trichlorodifluoropyridine (54732-62-6)

Guidance literature:

In sulfolane; molar ratio ClC5F4N/CaCl2 = 1/7.5; heating in vacuum (5 Torr) until 100 ml solvent are distilled off; addition of ethyleneglycol and heating to 210 °C (36 min);;

upstream raw materials:

Pentafluoropyridine

2,3,4,5,6-pentachloropyridine

3,5-dichloro-2,4,6-trifluoropyridine

3-chloro-2,4,5,6-tetrafluoropyridine

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