5203-15-6

Basic information

• Product Name: 4-(2-Methylpropoxy)benzonitrile
• Synonyms: 4-(2-Methylpropoxy)benzonitrile
• CAS NO: 5203-15-6
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 5203-15-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(2-Methylpropoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Methylpropoxy)benzonitrile(5203-15-6)
• EPA Substance Registry System: 4-(2-Methylpropoxy)benzonitrile(5203-15-6)

Safety Data

• Hazardous Substances Data: 5203-15-6(Hazardous Substances Data)

Usage

Uses

4-Isobutoxybenzonitrile is used as a reactant in the synthesis of Febuxostat.

Upstream product

• 513-38-2 Isobutyl iodide 
• 767-00-0 4-cyanophenol 
• 513-36-0 isobutyryl chloride 
• 78-83-1 2-methyl-propan-1-ol 
• 1194-02-1 4-fluorobenzonitrile 
• 78-77-3 Isobutyl bromide 
• 3328-57-2 sodium 4-cyanophenolate 

Downstream Products

• 4734-09-2 1-[4-(2-methylpropyloxy)phenyl]methanamine 
• 639863-75-5 1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene 
• 639863-77-7 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(piperidin-4-yl)urea 
• 706779-91-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide 
• 1080491-31-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N’-(4-(2-methylpropyloxy)phenylmethyl)carbamide tartaric acid 
• 955997-87-2 N,N'-bis(4-isobutoxybenzyl)urea 
• 1030513-44-0 4-isobutoxybenzamide 
• 706782-28-7 Pimavanserin tartrate 
• 221076-43-3 4-isobutoxybenzothioamide 
• 923942-34-1 methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 
• 1139901-88-4 tert-butyl 2-(3’-cyano-4’-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 
• 163597-57-7 3-cyanoisobutoxybenzothioamide 

Relevant articles and documents

PROCESS FOR THE MANUFACTURING OF PIMAVANSERIN

The present invention relates to a new process for manufacturing 1-(4-fluorobenzyl)-3-(4-iso-butoxyphenyl)-1-(1-methylpiperidin-4-yl)urea, with the INN name pimavanserin, and its hemitartrate salt.

A method for preparing [...] (by machine translation)

The invention discloses a method for preparing [...], comprises the following steps: 3 - chloromethyl - 4 - [...] with sodium bicarbonate reaction of material A; then with sodium hydrosulfide, sodium hydroxide reaction and get the substance B; then with 2 - chloro acetyl ethyl acetate reaction and get the substance C; then reacted with hydroxylamine hydrochloride and get the substance D, finally in the hydrolysis to obtain [...] under alkaline conditions. The material of the invention is cheap, simple and convenient operation, novel routes, environmental protection, high yield, the prepared [...] purity is good. (by machine translation)

Method for safely preparing pimavanserin and tartrate thereof by utilizing triphosgene

The invention discloses a method for safely preparing pimavanserin and tartrate thereof by utilizing triphosgene. The synthetic route is as shown in the specification. The raw materials used by the method disclosed by the invention are safe, the cost is low, and the production cost is effectively reduced. The method disclosed by the invention is mild in reaction conditions, usage of phosgene thatis high in toxicity and difficult to operate can be avoided, and industrial production is easily realized.