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Z-Leu-Leu-Gln-OH is a synthetic peptide consisting of three amino acids: Leucine (Leu), Leucine (Leu), and Glutamine (Gln), with a carboxy-terminal hydroxyl group (OH). The "Z" prefix indicates the presence of a benzyloxycarbonyl (Cbz) protecting group, which is commonly used in peptide synthesis to prevent unwanted side reactions. This peptide is often utilized in research and pharmaceutical applications, such as studying protein-protein interactions, drug design, and understanding the structure and function of biologically active peptides.

52060-87-4

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52060-87-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 52060-87-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,6 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52060-87:
(7*5)+(6*2)+(5*0)+(4*6)+(3*0)+(2*8)+(1*7)=94
94 % 10 = 4
So 52060-87-4 is a valid CAS Registry Number.

52060-87-4Relevant academic research and scientific papers

Zur Totalsynthese von Human-Sekretin

Wuensch, E.,Wendlberger, G.,Goehring, W.,Huebener, G.,Traving, B.

, p. 577 - 586 (2007/10/02)

The synthesis of the heptacosapeptide amide with the primary structure of Human-secretin is described.For this purpose 7 fragments were designed, i.e.H-Gly-Leu-Val-NH2 , Z-Arg(Z2)-Leu-Leu-Gln-OH , Z-Arg(Z2)-Leu-Gln-OH , Z-Arg(Z2)-Glu(OtBu)-Gly-Ala-OH , Z-Arg(Z2)-Leu-OH , Z-Thr(tBu)-Ser(tBu)-Glu(OtBu)-Leu-Ser(tBu)-OH , Adoc-His(Adoc)-Ser(tBu)-Asp(OtBu)-Gly-Thr(tBu)-Phe-OH ; these fragments were consequently assembled to the overall protected total sequence using the Wuensch/Weygand-method with dicyclohexylcarbodiimide.After deprotection by exposure to trifluoroacetic acid in presence of 1,2-ethanediol and water as scavenger, the islated crude product was purified by column chromatography on CM-Sepharose, fast flow.This synthesized Human-secretin showed the full biological activity in comparison to Porcine-secretin. Key words: Gastrointestinal hormone; Human-secretin: synthetic peptide factors.

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