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Z-Leu-Gln-OH, also known as N-benzyloxycarbonyl-leucyl-glutaminol, is a synthetic tripeptide consisting of three amino acids: leucine, glutamine, and a hydroxyl group. It is a derivative of the naturally occurring tripeptide Leu-Gln, with the addition of a benzyloxycarbonyl (Z) protecting group on the N-terminus. This modification is commonly used in peptide synthesis to prevent unwanted side reactions and ensure the correct sequence of amino acids during the assembly process. Z-Leu-Gln-OH is often employed as a building block in the synthesis of larger peptides and proteins, as well as in the study of peptide-protein interactions and the development of potential therapeutic agents.

39802-26-1

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39802-26-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 39802-26-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,8,0 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 39802-26:
(7*3)+(6*9)+(5*8)+(4*0)+(3*2)+(2*2)+(1*6)=131
131 % 10 = 1
So 39802-26-1 is a valid CAS Registry Number.

39802-26-1Relevant academic research and scientific papers

Zur Totalsynthese von Human-Sekretin

Wuensch, E.,Wendlberger, G.,Goehring, W.,Huebener, G.,Traving, B.

, p. 577 - 586 (1993)

The synthesis of the heptacosapeptide amide with the primary structure of Human-secretin is described.For this purpose 7 fragments were designed, i.e.H-Gly-Leu-Val-NH2 , Z-Arg(Z2)-Leu-Leu-Gln-OH , Z-Arg(Z2)-Leu-Gln-OH , Z-Arg(Z2)-Glu(OtBu)-Gly-Ala-OH , Z-Arg(Z2)-Leu-OH , Z-Thr(tBu)-Ser(tBu)-Glu(OtBu)-Leu-Ser(tBu)-OH , Adoc-His(Adoc)-Ser(tBu)-Asp(OtBu)-Gly-Thr(tBu)-Phe-OH ; these fragments were consequently assembled to the overall protected total sequence using the Wuensch/Weygand-method with dicyclohexylcarbodiimide.After deprotection by exposure to trifluoroacetic acid in presence of 1,2-ethanediol and water as scavenger, the islated crude product was purified by column chromatography on CM-Sepharose, fast flow.This synthesized Human-secretin showed the full biological activity in comparison to Porcine-secretin. Key words: Gastrointestinal hormone; Human-secretin: synthetic peptide factors.

Synthesis of PHI (Peptide Histidine Isoleucine) and Related Peptides and Immunochemical Confirmation of Amino Acid Residue in Position 24 of PHI with use of the Synthetic Peptides

Nokihara, K.,Yanaihara, C.,Iguchi, K.,Fukata, S.,Tanaka, M.,et al.

, p. 7909 - 7916 (2007/10/02)

An immunochemical approach, using synthetic peptides, was employed to establish the nature of residue 24 in the amino acid sequence of PHI (peptide histidine isoleucine).PHI(20-27) and 24>-PHI(20-27) were synthesized by conventional solutio

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