52067-89-7

Basic information

• Product Name: (+/-)-N-chloracetyl-α-(4-hydroxyphenyl)glycine
• Synonyms: (+/-)-N-chloracetyl-α-(4-hydroxyphenyl)glycine
• CAS NO: 52067-89-7
• Molecular Weight: 243.647
• Mol File: 52067-89-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+/-)-N-chloracetyl-α-(4-hydroxyphenyl)glycine(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-N-chloracetyl-α-(4-hydroxyphenyl)glycine(52067-89-7)
• EPA Substance Registry System: (+/-)-N-chloracetyl-α-(4-hydroxyphenyl)glycine(52067-89-7)

Safety Data

• Hazardous Substances Data: 52067-89-7(Hazardous Substances Data)

Upstream product

• 6324-01-2 p-hydroxyphenylglycine 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

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Treatment of the readily available (S)-(+) and (R)-(-) enantiomers of 2-aminobutan-1-ol 1 with sodium hydride followed by benzyl chloride, or a substituted benzyl halide, afforded the corresponding O-benzyl bases 4-7 in good yields. These new bases are recommended for the large scale resolution of racemic acids. For instance, they proved efficient for the practical resolutions of α-methylsuccinic acid (±)-9, N-acetylphenylglycine (±)-11, N-acetyl-(4-hydroxyphenyl) glycine (±)-14 and N-chloroacetyl-(4-hydroxyphenyl) glycine (±)-15.