52069-53-1Relevant academic research and scientific papers
Synthesis and Cyclization Reactions of 2-Amino-3-[(methoxycarbonyl)methylsulfonyl]pyrroles and Thiophene
Stephens, Chad E.,Walter Sowell Sr.
, p. 933 - 938 (2007/10/03)
The title aminopyrroles and thiophene have been prepared by condensation of methyl (cyanomethylsulfonyl)acetate with various α-amino ketones or 2-mercaptoacetaldehyde, respectively. Subsequent cyclization of these compounds by reaction between the amine and activated methylene has led to various ester-substituted thiazine- and thiadiazine-based bicyclic derivatives. In addition, cyclization of the title compounds by intramolecular coupling of the amine and ester has led to the analogous bicyclic thiazin-3(2H)-ones. Attempted hydrolysis of the ester-substituted bicyclics to the corresponding carboxylic acids was unsuccessful.
Regiochemistry and reactivity in the chlorination of sulfides
Hancock, James Reid,Hardstaff, William Rayne,Johns, Paul Alan,Langler, Richard Francis,Mantle, William Stanley
, p. 1472 - 1480 (2007/10/02)
Huheey's original method for the calculation of substituent electronegativities is modified so that isomeric groups have different electronegativities.The modified form of Huheey's method is then employed to show that our previously published method for anticipating regiochemistry in asymmetric sulfide chlorination, i.e., ΔXP calculations for the α and α' substituents in the sulfide substrates, is successful in all fifty known cases.A new reactivity function (RP) is defined, for the sulfenium ion intermediates, which permits one to anticipate when substrates become inert to chlorine in exhaustive chlorinations conducted in aprotic media.
Cyanomethylthioacetylcephalosporins
-
, (2008/06/13)
New cyanomethylthioacetylcephalosporins of the following general formula, and their salts SPC1 Wherein R is hydrogen or a salt forming ion of the group consisting of aluminum, alkali metal, alkaline earth metal, lower alkylamine, phenyl-lower alkylamine,
