52094-96-9Relevant academic research and scientific papers
Anti-hepatic fibrosis compound, preparation, preparation method and application
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Paragraph 0029; 0034-0035, (2021/03/05)
The invention belongs to the technical field of medicines, in particular to an anti-hepatic fibrosis compound, a preparation, a preparation method and application, and the structural formula of the anti-hepatic fibrosis compound is shown in the specification. The anti-hepatic fibrosis compound can obviously improve hepatic fibrosis, improve liver function indexes, reduce extracellular matrix accumulation of collagen and the like in extracellular interstitial substances, reduce the degree of hepatic fibrosis and inhibit the formation and development of hepatic fibrosis.
Novel 1,3,4-oxadiazole thioether derivatives containing flexible-chain moiety: Design, synthesis, nematocidal activities, and pesticide-likeness analysis
Chen, Jixiang,Hu, Deyu,Luo, Yuqin,Song, Baoan,Wei, Chengqian,Wu, Rong,Wu, Sikai
, (2020/02/27)
Seventy-two novel 1,3,4-oxadiazole thioether derivatives containing different flexible-chain moieties were designed and synthesized. The nematicidal activities of all the title compounds were evaluated, and some compounds showed excellent nematicidal acti
Anti-hepatic fibrosis compound and preparation as well as preparation method and application of compound
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Paragraph 0030; 0034; 0035, (2020/01/12)
The invention belongs to the technical field of medicines, and in particular relates to an anti-hepatic fibrosis compound and a preparation as well as a preparation method and application of the compound. A structural formula of the anti-hepatic fibrosis compound is shown in the specification. The anti-hepatic fibrosis compound can obviously improve hepatic fibrosis, improve liver function indexes, reduce accumulation of extracellular matrixes such as collagen in extracellular interstitial substances, reduce the degree of the hepatic fibrosis and inhibit the formation and development of the hepatic fibrosis.
Synthesis and Insecticidal Evaluation of Novel N-pyridylpyrazole Derivatives Containing Diacylhydrazine/1,3,4-Oxadiazole Moieties
Wang, Wei,Zheng, Xiao-Rui,Huang, Xiao-Ying,Mao, Ming-Zhen,Liu, Kang-Yun,Xue, Chao,Wang, Lie-Ping,Ning, Bin-Ke
, p. 1330 - 1336 (2019/01/30)
Two series of novel N-pyridylpyrazole derivatives containing diacylhydrazine/1,3,4-oxadiazole moieties were designed and synthesized based on the structure of chlorantraniliprole and characterized via 1H-NMR, 13C-NMR, IR, MS, and elemental analysis. The preliminary bioassay indicated that some of the title compounds I and II exhibited larvicidal activities against Mythimna separata with 90–100% death rates at 500?mg/L. The further test showed that these compounds had weak insecticidal activity against Mythimna separata and Plutella xylostella at 200?mg/L and might be not suitable as insecticide lead compound for further optimization.
Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents
Turan-Zitouni, Guelhan,Kaplancikli, Zafer Asim,Oezdemir, Ahmet,Chevallet, Pierre,Kandilci, Hilmi Burak,Guemuesel, Buelent
, p. 586 - 590 (2008/12/21)
The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/alkyl-5-(1-phenoxyethyl)-3-[N-(substituted) acetamido]thio-4H-1,2,4-t
Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1- phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives
Turan-Zitouni, Guelhan,Kaplancikli, Zafer Asim,Yildiz, Mehmet Taha,Chevallet, Pierre,Kaya, Demet
, p. 607 - 613 (2007/10/03)
The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new thiazole derivatives of triazoles were synthesize
