95262-84-3

Upstream product

• 67-56-1 methanol 
• 3307-39-9 2-(4-chlorophenoxy)propionic acid 
• 5445-17-0 Methyl 2-bromopropionate 
• 1121-74-0 potassium 4-chlorophenoxide 
• 4878-20-0 2-(4-Chlorophenoxy)propionic acid chloride 
• 106-48-9 4-chloro-phenol 
• 4841-22-9 (4-chloro-phenoxy)-acetic acid methyl ester 
• 616-38-6 carbonic acid dimethyl ester 
• 186581-53-3 diazomethane 
• 2065-24-9 methyl 2-phenoxypropanoate 
• 108-95-2 phenol 
• 66648-29-1 methyl 2-{[(4-methylphenyl)sulfonyl]oxy}propanoate 

Downstream Products

• 52094-96-9 2-(4-chlorophenoxy)propionyl hydrazide 
• 3307-39-9 2-(4-chlorophenoxy)propionic acid 
• 3307-39-9 (R)-2-(4-chlorophenoxy)propanoic acid 
• 3307-39-9 (S)-2-(4-chlorophenoxy)propionic acid 
• 99210-92-1 (R)-2-(4-chlorophenoxy)propanoic acid methyl ester 
• 95342-42-0 (S)-2-(4-chlorophenoxy)propionic acid methyl ester 
• 51963-52-1 2-<4-Chlorphenoxy>-propionsaeureisopropylhydrazid 
• 90299-71-1 2-(2-(4-chlorophenoxy)propionyl)-N-phenylhydrazine thioformamide 
• 90327-19-8 5-(1-(4-chlorophenoxy)ethyl)-4-phenyl-4H-1,2,4-triazole-3-thiol 
• 403990-79-4 2-((5-(1-(4-chlorophenoxy)ethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-((1,5-dimethyl-3)-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide 
• 63650-24-8 2-(4-chlorophenoxy)-1-propanol 
• 82703-23-9 O-[2-(4-chlorophenoxy)propyl]hydroxylamine 

Relevant academic research and scientific papers

Anti-hepatic fibrosis compound, preparation, preparation method and application

The invention belongs to the technical field of medicines, in particular to an anti-hepatic fibrosis compound, a preparation, a preparation method and application, and the structural formula of the anti-hepatic fibrosis compound is shown in the specification. The anti-hepatic fibrosis compound can obviously improve hepatic fibrosis, improve liver function indexes, reduce extracellular matrix accumulation of collagen and the like in extracellular interstitial substances, reduce the degree of hepatic fibrosis and inhibit the formation and development of hepatic fibrosis.

Cyclohexane-1,3-diketone compound as well as synthesis method and application thereof

The invention provides a cyclohexane-1,3-diketone compound of which the structural formula is shown in the specification, wherein the group R1 in the structural formula I is -CH3, -CH2CH3, -(CH2)2CH3,-CH(CH3)2, -(CH2)3CH3, -CH(CH3)C2H5, -CH2CH(CH3)2 or -C

Anti-hepatic fibrosis compound and preparation as well as preparation method and application of compound

The invention belongs to the technical field of medicines, and in particular relates to an anti-hepatic fibrosis compound and a preparation as well as a preparation method and application of the compound. A structural formula of the anti-hepatic fibrosis compound is shown in the specification. The anti-hepatic fibrosis compound can obviously improve hepatic fibrosis, improve liver function indexes, reduce accumulation of extracellular matrixes such as collagen in extracellular interstitial substances, reduce the degree of the hepatic fibrosis and inhibit the formation and development of the hepatic fibrosis.

Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT6 serotonin receptor among substituted 1,3,5-triazinylpiperazines

A series of 2-amino-4-(4-methylpiperazin-1-yl)-1,3,5-triazines was designed based on previously published 2-amino-4-benzyl-(4-methylpiperazin-1-yl)-1,3,5-triazines in order to evaluate the role of a linker between the triazine moiety and an aromatic substituent for the human serotonin 5-HT6 receptor affinity. As new linkers two carbon atoms (ethyl or ethenyl) or an oxyalkyl chain (methoxy, 2-ethoxy, 2-propoxy) were introduced. Affinities of the compounds for the 5-HT6R as the main target, and for the 5-HT1AR, 5-HT7R and D2R as competitive ones, were determined in the radioligand binding assays. Docking to the 5-HT6R homology model was performed to support SAR analysis. Results showed that the branching of the methoxyl linker increased affinity for the human 5-HT6R whereas an unsaturated bond within the linker dramatically reduced desirable activity. Both experimental and theoretical studies confirmed the previously postulated beneficial role of the aromatic size for interaction with the 5-HT6R. Thus, the largest naphthyl moiety yielded the highest activity. In particular, 4-(4-methylpiperazin-1-yl)-6-(1-(naphthalen-1-yloxy)ethyl)-1,3,5-triazin-2-amine (24), the most potent 5-HT6R agent found (Ki = 23 nM), can be a new lead structure for further search and development.

A phenoxy carboxylic acid ester herbicide preparation method (by machine translation)

The invention provides a phenoxy carboxylic acid ester herbicide preparation method, including: S1, phenol in the presence of alkaline substance with the chlorinated carboxylic acid ester condensation reaction, phenoxy carboxylic acid ester obtained; the ClR states the chloro- carboxylic acid ester of the general formula1 COOR, R1 Is C1 - 3 alkylene or alkylidene, R is C1 - 10 alkyl or C3 - 10 cycloalkyl; S2, the [...] ester in the 1st and 2nd catalyst the presence of a catalyst, with the chlorinating agent to carry out the selective chlorination of, get [...] ester; the Lewis acid catalyst is selected from the 1st, the 2nd catalyst is C5 - 22 of the thioether, thiazole, thiophene compounds or different benzisothiazoles; S3, will the [...] ester with an alcohol reaction, as shown in formula I phenoxy carboxylic acid ester herbicide; R3 Is H, Cl or CH3 , R ' is a C4 - 20 alkyl or cycloalkyl. This invention can improve the product quality and the production environment, three waste low. (by machine translation)

Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column

A technique based on liquid chromatography has been developed to facilitate studies of enantioselectivity in penicillin G acylase (PGA)-catalyzed hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues. PGA was covalently immobilized on an aminopropyl monolithic silica support to create an immobilized HPLC-enzyme reactor. Two sets of experimental data were drawn to calculate the enantioselectivity (E) of the kinetically controlled enantiomer-differentiating reaction, the degree of substrate conversion and the enantiomeric excess of the product. The developed enzymatic reactor was coupled through a switching valve to an achiral analytical column for separation and quantitation of the hydrolysis products. The enantiomeric excess was determined off-line on a PGA-chiral stationary phase. In this way, highly precise E values were determined. A computational study related to the hydrolysis of the considered racemic esters was also carried out in order to unambiguously clarify both the substrate specificity and the enantioselectivity displayed by PGA.

Candida cylindracea lipase-mediated kinetic resolution of α-substituted α-aryloxyacetic acid methyl esters

Hydrolysis of several α-alkyl-α-aryloxyacetic acid methyl esters and of α-methyl-α-(n-propyl)-α-(p-chlorophenoxy)acetic acid methyl ester were performed in the presence of Candida cylindracea lipase. The α-alkyl-α-aryloxyacetic acid methyl esters and α-methyl-α-(n-propyl)-α-(p-chlorophenoxy)acetic acid methyl ester were incubated in buffer phosphate (pH 7-8). The reaction mixture, containing the unreacted ester and corresponding acid, showed enantiomeric excesses (ee) up to 81%. The extent of conversion was quite low for the α-methyl-α-(n-propyl)-α-(p-chlorophenoxy)acetic acid methyl ester, the corresponding acid was obtained with ee > 98%.

A new synthesis of 2-aryloxypropionic acids derivatives via selective mono-C-methylation of methyl aryloxyacetates and aryloxyacetonitriles with dimethyl carbonate

A one-pot procedure for the mono-C-methylation of methyl aryloxyacetates and aryloxyaceto nitriles by dimethyl carbonate (DMC) is reported. The reaction is carried out in an autoclave at high temperatures (180-200°C) and in the presence of a base (K2

Optical resolution of aryloxypropionic acids and their esters by HPLC on cellulose tris-3,5-dimethyl-triphenylcarbamate derivative

Chiral chromatographic resolution of a series of antiphlogistic 2- aryloxypropionic acids and their methyl and ethyl esters was performed using a Chiralcel OD column. The CSP selected resolved most of the acids and esters efficiently, the enantiomers being well separated without requiring time consuming analysis. Chromatographic separation of R enriched samples was performed to determine the correct elution order. Using eluting systems such as hexane and 2-propanol, or hexane, 2-propanol and formic acid, the S enantiomer of all acids and esters was always found to elute first. We also considered the role of electron-donating or electron-withdrawing substituents (at the aryloxylic moiety) on the chiral resolution. It was shown that the electronic features of the substituents have more influence on the chiral interactions between the solutes and the CSP than their steric hindrance. Finally we determined, by molecular models, the interaction between CSP and solutes. In this way were able to determine all the potential sites for interactions, which are compatible with the conformations of the compounds and the structure of the stationary phase, and point out those interactions which enable chiral resolution.

Enzyme catalysed hydrolysis of chlorophenoxypropionates

We report on the enzymatic hydrolysis of methyl 2-phenoxypropionate and of the following chlorinated derivatives: methyl o-chloro-, m-chloro-, p-chloro-, and o,p-dichloro-2-phenoxypropionates. α-Chymotripsyn, lipase, and pig liver esterase have an R enantioselectivity whereas subtilisin has an S enantioselectivity.Enantiomeric excess (e.e.) cover a wide range (from 5 to 100percent).