52117-13-2

Basic information

• Product Name: N-(alpha,alpha-dimethylphenethyl)formamide
• Synonyms: N-(alpha,alpha-dimethylphenethyl)formamide;N-(1,1-Dimethyl-2-phenylethyl)formamide;Einecs 257-667-8;2-Methyl-3-phenyl-2-N-forMylaMinopropane;N-(α,α-DiMethylphenethyl)forMaMide;N-ForMyl-α,α-diMethyl-β-phenethylaMine;α,α-DiMethylphenethylforMaMide;N-(A,A-DIMETHYLPHENETHYL)FORMAMIDE
• CAS NO: 52117-13-2
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• EINECS: 257-667-8
• Product Categories: Aromatics;Intermediates
• Mol File: 52117-13-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 63-64 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 340.8°Cat760mmHg
• Flash Point: 201.9°C
• Appearance: /
• Density: 0.995g/cm³
• PKA: 16.34±0.23(Predicted)
• CAS DataBase Reference: N-(alpha,alpha-dimethylphenethyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(alpha,alpha-dimethylphenethyl)formamide(52117-13-2)
• EPA Substance Registry System: N-(alpha,alpha-dimethylphenethyl)formamide(52117-13-2)

Safety Data

• Hazardous Substances Data: 52117-13-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

α,α-Dimethylphenethylformamide is a α,α-dimethylated N-formyl phenthylamine derivative. α,α-Dimethylphenethylformamide is used in the preparation of its N-methyl analogue which is a known sympathomimetic.

Upstream product

• 3290-53-7 2-methyl-1-phenyl-2-propene 
• 143-33-9 sodium cyanide 
• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 64-18-6 formic acid 
• 122-09-8 Phentermin 
• 1589-82-8 phenylmagnesium bromide 
• 768-49-0 (2-methyl-1-propenyl)-benzene 

Downstream Products

• 122-09-8 Phentermin 
• 71475-23-5 N-Butyl-N-(1,1-dimethyl-2-phenyl-ethyl)-formamide 
• 71475-24-6 N-Benzyl-N-(1,1-dimethyl-2-phenyl-ethyl)-formamide 
• 28460-55-1 3,3-dimethyl-3,4-dihydroisoquinoline 
• 52497-67-3 2-Benzyl-2-Nitrosopropan 
• 148671-62-9 3,3-dimethyl-3,4-dihydroisoquinoline N-oxide 
• 69716-73-0 N-(1,1-dimethyl-2-phenyl-ethyl)-glycine nitrile 
• 79706-47-1 N-formyl-2-{4-acetylphenyl}-1,1-dimethylethanamine 

Relevant articles and documents

Synthesis and reactivity study of two new dihydroisoquinoline-derived oxaziridines

The N-alkyl oxaziridines may be used as reagents for the oxidation of sulfides in acid-promoted reactions. The present work describes the behavior of two newly synthesized dihydroisoquinoline-derived oxaziridines with respect to methanesulfonic acid. An isomerization reaction was observed in the absence of sulfide.

Kinetic studies of the reaction of some nitrosoalkanes with nitrogen dioxide

The rates of the oxidation of some nitrosoalkanes (CH3)2C(CH2X)NO by nitrogen dioxide in carbon tetrachloride have been studied by stopped-flow techniques, and have been found to exhibit second order kinetics. Arrhenius parameters have been determined for the cases of X = H, CH3, C(CH3)3, C6H5, NO2, Cl and OCOCH3. Electron withdrawing substituents are found to decrease significantly the rates, which are generally much faster than the corresponding oxidation of nitrosoarenes. The results obtained are discussed with reference to the Hammett σ constants of the substituents X, and the atomic charges at the nitrogen atom as given by the TNDO/2 method, the geometries of the molecules having been optimised by the PM3 semi-empirical method.

Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides

The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. Copyright