52117-13-2

Usage

Uses

Used in Pharmaceutical Industry:
N-(alpha,alpha-dimethylphenethyl)formamide is used as an intermediate in the synthesis of its N-methyl analogue, which is a known sympathomimetic agent. This application is due to its chemical structure that allows for the preparation of compounds with potential pharmacological activities.
Used in Chemical Synthesis:
As a white solid with specific chemical properties, N-(alpha,alpha-dimethylphenethyl)formamide can be used as a starting material or intermediate in the synthesis of other related compounds. Its unique structure makes it a valuable component in the development of new chemical entities for various applications.

Upstream product

• 3290-53-7 2-methyl-1-phenyl-2-propene 
• 143-33-9 sodium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 1589-82-8 phenylmagnesium bromide 
• 64-18-6 formic acid 
• 122-09-8 Phentermin 
• 151-50-8 potassium cyanide 
• 768-49-0 (2-methyl-1-propenyl)-benzene 

Downstream Products

• 122-09-8 Phentermin 
• 52497-67-3 2-Benzyl-2-Nitrosopropan 
• 79706-47-1 N-formyl-2-{4-acetylphenyl}-1,1-dimethylethanamine 
• 69716-73-0 N-(1,1-dimethyl-2-phenyl-ethyl)-glycine nitrile 
• 148671-62-9 3,3-dimethyl-3,4-dihydroisoquinoline N-oxide 
• 28460-55-1 3,3-dimethyl-3,4-dihydroisoquinoline 
• 71475-24-6 N-Benzyl-N-(1,1-dimethyl-2-phenyl-ethyl)-formamide 
• 71475-23-5 N-Butyl-N-(1,1-dimethyl-2-phenyl-ethyl)-formamide 

Relevant academic research and scientific papers

Synthesis and reactivity study of two new dihydroisoquinoline-derived oxaziridines

The N-alkyl oxaziridines may be used as reagents for the oxidation of sulfides in acid-promoted reactions. The present work describes the behavior of two newly synthesized dihydroisoquinoline-derived oxaziridines with respect to methanesulfonic acid. An isomerization reaction was observed in the absence of sulfide.

AMINOALCOHOL DERIVATIVES

The present invention relates to a compound formula[I]: wherein X is bond or -O-, R1 is formula[A] or formula [B] in which R5, R6 and R7 are each as defined in the description, R2 is hydrogen or lower alkyl, R3 is hydrogen or an amino protective group , R4 is formula[C], [D] or [E] in which R8, R9, R10, R11, R12, R13 and R16are each as defined in the description, and R14 and R15 are each independently hydrogen or lower alkyl, or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of overactive bladder, micturiation disorder and the like.

Kinetic studies of the reaction of some nitrosoalkanes with nitrogen dioxide

The rates of the oxidation of some nitrosoalkanes (CH3)2C(CH2X)NO by nitrogen dioxide in carbon tetrachloride have been studied by stopped-flow techniques, and have been found to exhibit second order kinetics. Arrhenius parameters have been determined for the cases of X = H, CH3, C(CH3)3, C6H5, NO2, Cl and OCOCH3. Electron withdrawing substituents are found to decrease significantly the rates, which are generally much faster than the corresponding oxidation of nitrosoarenes. The results obtained are discussed with reference to the Hammett σ constants of the substituents X, and the atomic charges at the nitrogen atom as given by the TNDO/2 method, the geometries of the molecules having been optimised by the PM3 semi-empirical method.

A novel modification of the Ritter reaction using trimethylsilyl cyanide

A new modification of the Ritter reaction using trimethylsilyl cyanide (Me3SiCN) is described, which converts alcohols to their corresponding formamides in high yields using a convenient procedure. The reaction conditions and mechanism are discussed. In some cases, new formamides are synthesized which cannot be prepared by the classical Ritter reaction.

Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides

The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. Copyright