521273-76-7

Usage

Uses

Used in Pharmaceutical Applications:
Piperidin-4-ylmethyl-pyrimidin-2-yl-amine is used as a potential candidate for pharmaceutical applications due to its unique structure and the presence of a pyrimidin-2-yl-amine group, which may offer opportunities for the development of new drugs or drug delivery systems.
Used in Synthetic Chemistry Applications:
Piperidin-4-ylmethyl-pyrimidin-2-yl-amine is used as a building block or intermediate in synthetic chemistry for the synthesis of more complex molecules, potentially leading to the discovery of novel compounds with various applications in different industries.

InChI:InChI=1/C10H16N4/c1-4-12-10(13-5-1)14-8-9-2-6-11-7-3-9/h1,4-5,9,11H,2-3,6-8H2,(H,12,13,14)

Upstream product

• 7144-05-0 4-Aminomethylpiperidine 
• 455265-89-1 4-[(5-fluoro-pyrimidin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester 
• 1722-12-9 2-chloropyrimidine 
• 455267-58-0 5-fluoro-N-(piperidin-4-ylmethyl)pyrimidin-2-amine 
• 157023-34-2 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester 
• 455265-24-4 benzyl 4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate 

Downstream Products

• 1374602-21-7 C₂₈H₃₉ClN₆O₂ 

Relevant academic research and scientific papers

Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2- ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist

The discovery of a novel series of NR2B subtype selective N-methyl-D-aspartate (NMDA) antagonists is reported. Initial optimization of a high-throughput screening lead afforded an aminopyridine derivative 13 with significant NR2B antagonist potency but limited selectivity over hERG-channel and other off-target activities. Further structure-activity studies on the aminoheterocycle moiety and optimization of the carbamate led to the highly potent 2-aminopyrimidine derivative 20j with a significantly improved off-target activity profile and oral bioavailability in multiple species coupled with good brain penetration. Compound 20j demonstrated efficacy in in vivo rodent models of antinociception, allodynia, and Parkinson's disease.

N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists

Compounds represented by Formula (I): 1or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.