521291-07-6Relevant academic research and scientific papers
Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents
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, (2008/06/13)
This invention provides estrogen receptor modulators of formula 1, having the structure wherein X, Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are as defined in the specificati
Constrained phytoestrogens and analogues as ERβ selective ligands
Miller, Chris P.,Collini, Michael D.,Harris, Heather A.
, p. 2399 - 2403 (2007/10/03)
A new series of ERbeta (ERβ) selective ligands has been prepared. One of the compounds 6, structurally related to the phytoestrogen apigenin 4, displays a binding preference for ERβ over ERα of over 40-fold. In addition to its binding selectivity, 6 was a
