521300-99-2

Basic information

• Product Name: (R)-tamsarocin (-)-camphor-10-sulfonate
• Synonyms: (R)-tamsarocin (-)-camphor-10-sulfonate
• CAS NO: 521300-99-2
• Molecular Weight: 640.819
• Mol File: 521300-99-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-tamsarocin (-)-camphor-10-sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tamsarocin (-)-camphor-10-sulfonate(521300-99-2)
• EPA Substance Registry System: (R)-tamsarocin (-)-camphor-10-sulfonate(521300-99-2)

Safety Data

• Hazardous Substances Data: 521300-99-2(Hazardous Substances Data)

Upstream product

• 35963-20-3 (R)-10-camphorsulfonic acid 
• 94666-07-6 5-[2-[2-(2-ethoxyphenoxy)-ethylamino]-2-methylethyl]-2-methoxybenzenesulfonamide 
• 112244-38-9 (+/-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 3259-03-8 2-(o-ethoxyphenoxy)-ethyl bromide 
• 80223-79-6 2-methoxy-5-(2-oxopropyl)benzenesulfonyl chloride 
• 116091-63-5 2-methoxy-5-(2-oxopropyl)benzenesulfonamide 
• 6781-16-4 (2-ethoxyphenoxy)methyl cyanide 
• 106463-17-6 (+)-Tamsulosin 
• 106133-20-4 (R)-tamsulosin 

Downstream Products

• 106133-20-4 tamsulosin hydrochloride 

Relevant articles and documents

Method of resolving tamsulosin enantiomer

The invention relates to a method of resolving tamsulosin enantiomer, and in particular, relates to a method of resolving tamsulosin, represented as the formula (I), into an R-enantiomer and an S-enantiomer. The method includes the steps of: (a) dissolving a solid mixture of (R)-tamsulosin free alkali and (S)-tamsulosin free alkali in a solvent and performing a reaction to the free alkalis with camphor-10-sulfonic acid to form a solution containing a pair of diastereomeric camphor-10-sulfonates of tamsulosin, and then preferentially precipitating one diastereomeric camphor-10-sulfonate of the tamsulosin from the solution containing a pair of the diastereomeric camphor-10-sulfonates of tamsulosin, thereby forming a precipitate, in which one diastereomer is enriched, and a solute, in which the other one diastereomer is enriched; and (b) from one of the precipitate and the solute, releasing tamsulosin free alkali to obtain optical-rotation-enriched tamsulosin free alkali. The method has excellent technical performance.