5215-40-7

Basic information

• Product Name: 2,4,6-trimethyl-N-phenylbenzamide
• Synonyms: benzamide, 2,4,6-trimethyl-N-phenyl-
• CAS NO: 5215-40-7
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.3123
• Mol File: 5215-40-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 327.9°C at 760 mmHg
• Flash Point: 198.3°C
• Density: 1.102g/cm³
• Vapor Pressure: 0.000196mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 2,4,6-trimethyl-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-trimethyl-N-phenylbenzamide(5215-40-7)
• EPA Substance Registry System: 2,4,6-trimethyl-N-phenylbenzamide(5215-40-7)

Safety Data

• Hazardous Substances Data: 5215-40-7(Hazardous Substances Data)

Usage

General Description

2,4,6-trimethyl-N-phenylbenzamide, also known as mesitaldehyde, is an organic compound with the chemical formula C15H15NO. It is a white to light yellow solid with a faint, aromatic odor and is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a fragrance ingredient and flavoring agent in the production of perfumes and food products. This chemical is known for its high melting point and is considered to be stable under normal conditions. However, it may react with strong oxidizing agents and should be handled with care to avoid potential hazards.

Upstream product

• 103-71-9 phenyl isocyanate 
• 108-67-8 1,3,5-trimethyl-benzene 
• 487-68-3 mesytaldehyde 
• 62-53-3 aniline 
• 4930-03-4 phenyl N-phenylcarbamate 
• 36600-83-6 tris(mesityl)boroxin 
• 1754-55-8 ethyl 2,4,6-trimethylbenzoate 
• 1734-17-4 phenyl 2,4,6-trimethyl benzoate 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 480-63-7 mesitylenecarboxylic acid 
• 60324-03-0 dimesityldioxomolybdenum(VI) 
• 116881-11-9 dimesityl-di(t-butylimido)molybdenum(VI) 

Downstream Products

• 259817-05-5 ethyl 2-diazo-3-oxo-3-[N-(2,4,6-trimethylbenzoyl)-N-phenylamino]-propanoate 
• 5215-45-2 N-([1,1'-biphenyl]-2-yl)-2,4,6-trimethylbenzamide 
• 259817-10-2 5-ethoxycarbonyl-2-(2,4,6-trimethylphenyl)-3-phenyl-1,3-oxazolium-4-olate 
• 1146-85-6 4-aminophenylmesitylketone 
• 34192-76-2 2-amino-2',4',6'-trimethylbenzophenone 
• 62-53-3 aniline 
• 68971-47-1 N-(mesityl)benzimidoyl chloride 

Relevant articles and documents

Chromium-catalyzed ligand-free amidation of esters with anilines

Amides are important structural motifs in pharmaceutical and agrochemical chemistry because of the intriguing biological active properties. We report here the amidation of commercially available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution.

Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.