5216-23-9

Usage

Uses

Used in Research and Development:
4-(4-carboxy-2,3,5,6-tetrafluoro-phenyl)-2,3,5,6-tetrafluoro-benzoic acid is used as a research compound for studying the reactivity and behavior of organic compounds. Its unique structure allows scientists to explore the effects of fluorination on aromatic systems and their potential applications in various fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(4-carboxy-2,3,5,6-tetrafluoro-phenyl)-2,3,5,6-tetrafluoro-benzoic acid is used as a key intermediate in the synthesis of various drug molecules. Its fluorinated aromatic structure can enhance the pharmacokinetic and pharmacodynamic properties of the resulting compounds, leading to improved therapeutic efficacy.
Used in Agrochemical Industry:
4-(4-carboxy-2,3,5,6-tetrafluoro-phenyl)-2,3,5,6-tetrafluoro-benzoic acid is utilized as a building block in the development of agrochemicals, such as pesticides and herbicides. Its fluorinated structure can impart enhanced biological activity and selectivity, making it a valuable component in the design of novel agrochemicals.
Used in Materials Science:
In the field of materials science, 4-(4-carboxy-2,3,5,6-tetrafluoro-phenyl)-2,3,5,6-tetrafluoro-benzoic acid is employed as a precursor for the synthesis of advanced materials with unique properties. Its fluorinated aromatic structure can contribute to the development of materials with improved thermal stability, chemical resistance, and other desirable characteristics.

Upstream product

• 36629-42-2 methyl pentafluorobenzoate 
• 34265-97-9 dimethyl 2,2',3,3',5,5',6,6'‐octafluoro‐[1,1'‐biphenyl]‐4,4'‐dicarboxylate 
• 1173285-26-1 diethyl 2,2',3,3',5,5',6,6'-octafluorobiphenyl-4,4'-dicarboxylate 
• 4522-93-4 ethyl pentafluorobenzoate 
• 28442-30-0 1,1’-(dicyano)-2,2’,3,3’,5,5’,6,6’-octafluoro-4,4’-biphenyl 
• 31469-85-9 4-iodo-2,3,5,6-tetrafluoro-benzonitrile 
• 5216-17-1 2,3,5,6-tetrafluorobenzonitrile 
• 124-38-9 carbon dioxide 
• 3883-86-1 2,2',3,3',5,5',6,6'-octafluoro-1,1'-biphenyl 

Downstream Products

• 1447045-22-8 Cu(2,2',3,3',5,5',6,6'-octafluorobiphenyl-4,4'-dicarboxylate)(MeOH) 

Relevant academic research and scientific papers

Structural diversity of zinc(ii) coordination polymers with octafluorobiphenyl-4,4′-dicarboxylate based on mononuclear, paddle wheel and cuboidal units

We present a series of six novel Zn(ii) complexes containing anions of perfluorinated biphenyl-4,4′-dicarboxylate (oFBPDC2?). Among them are the 0D complex [Zn(eg)3](oFBPDC) (eg = ethylene glycol), the 1D [Zn(H2O)(ur)(oFBPDC)] (ur = urotropine) and [Zn(CH3OH)2(CH3OCH2CH2OH)(oFBPDC)] and the 2D layered [Zn2(CH3CN)2(oFBPDC)2]·2C6H6·2CH3CN, [Zn2(H2O)2(oFBPDC)2]·4(CH3)2CO, [{Zn4(μ3-OCH3)4}(CH3OH)4(oFBPDC)2]·[{Zn4(μ3-OCH3)4}(H2O)(CH3OH)3(oFBPDC)2]·13CH3OH. The latter coordination polymer is built up by unique Zn4(OCH3)4 cuboidal units. The complexes are characterized by single-crystal X-ray diffraction, FT-IR, elemental analysis, and TGA. Investigation of the CO2 adsorption at 195 K on [Zn2(CH3CN)2(oFBPDC)2] and [Zn2(H2O)2(oFBPDC)2] of the layered polymeric structure revealed that they have BET surface areas of 334.8 and 150.6 m2 g?1, respectively.

Tuning Lewis Acidity of Metal-Organic Frameworks via Perfluorination of Bridging Ligands: Spectroscopic, Theoretical, and Catalytic Studies

The Lewis acidity of metal-organic frameworks (MOFs) has attracted much research interest in recent years. We report here the development of two quantitative methods for determining the Lewis acidity of MOFs - based on electron paramagnetic resonance (EPR) spectroscopy of MOF-bound superoxide (O2?-) and fluorescence spectroscopy of MOF-bound N-methylacridone (NMA) - and a simple strategy that significantly enhances MOF Lewis acidity through ligand perfluorination. Two new perfluorinated MOFs, Zr6-fBDC and Zr6-fBPDC, where H2fBDC is 2,3,5,6-tetrafluoro-1,4-benzenedicarboxylic acid and H2fBPDC is 2,2′,3,3′,5,5′,6,6′-octafluoro-4,4′-biphenyldicarboxylic acid, were shown to be significantly more Lewis acidic than nonsubstituted UiO-66 and UiO-67 as well as the nitrated MOFs Zr6-BDC-NO2 and Zr6-BPDC-(NO2)2. Zr6-fBDC was shown to be a highly active single-site solid Lewis acid catalyst for Diels-Alder and arene C-H iodination reactions. Thus, this work establishes the important role of ligand perfluorination in enhancing MOF Lewis acidity and the potential of designing highly Lewis acidic MOFs for fine chemical synthesis.

Synthesis of Octafluorobiphenyl-4,4′-dicarboxylic acid and photoluminescent compounds based thereon

Octafluorobiphenyl-4,4′-dicarboxylic acid (H2L) and its complexes with Tb(III) and Eu(III) [Ln2(H2O)4(L)3·3H2O and Ln2(phen)2(L)3·2H2O] have been prepared; their structure has been elucidated from IR spectroscopy and X-ray diffraction analysis data. Thermal properties of the compounds have been studied. The complexes of Tb(III) and Eu(III) exhibit green and red photoluminescence, respectively.

Superhydrophobic perfluorinated metal-organic frameworks

Three perfluorinated Cu-based metal-organic frameworks (MOFs) were prepared starting from extensively fluorinated biphenyl-based ligands accessed via C-H functionalization. These new materials are highly hydrophobic: with water contact angles of up to 151