52163-89-0

Basic information

• Product Name: 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98
• Synonyms: 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98;3-(2-Fluorophenyl)propionyl chloride 98%;3-(2-Fluorophenyl)propionyl chloride, HPLC 98%;Benzenepropanoyl chloride, 2-fluoro-
• CAS NO: 52163-89-0
• Molecular Formula: C₉H₈ClFO
• Molecular Weight: 186.6122
• Mol File: 52163-89-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 245.3°Cat760mmHg
• Flash Point: 102.2°C
• Appearance: /
• Density: 1.231g/cm³
• CAS DataBase Reference: 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98(52163-89-0)
• EPA Substance Registry System: 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98(52163-89-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 52163-89-0(Hazardous Substances Data)

Usage

General Description

3-(2-Fluorophenyl)propionyl chloride 98 is a chemical compound with the molecular formula C9H8ClF and a molecular weight of 174.61 g/mol. It is a colorless to pale yellow liquid with a strong, pungent odor. 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98 is used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also a valuable building block for the production of various organic compounds. Additionally, it is utilized in the manufacture of dyes and other specialty chemicals. 3-(2-Fluorophenyl)propionyl chloride 98 should be handled with caution, as it is corrosive and may cause skin and eye irritation upon contact. Proper safety precautions should be taken when working with this chemical.

Upstream product

• 79-37-8 oxalyl dichloride 
• 1643-26-1 3-(2-fluorophenyl)propionic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 451-69-4 2-fluorocinnamic acid 
• 59223-72-2 diethyl 2-(2-fluorophenyl)ethane-1,1-dicarboxylate 
• 446-48-0 o-fluorobenzyl bromide 

Downstream Products

• 699-99-0 4-fluoro-1-indanone 
• 156484-68-3 2-bromo-4-fluoro-1-indanone 
• 872181-31-2 2-fluoro-6-(4-fluoroindan-1-yloxy)-benzonitrile 
• 1267272-12-7 1,1,1-trifluoro-4-(2-fluorophenyl)butan-2-one 
• 52085-95-7 4-fluoro-indan-1-ol 
• 91319-66-3 3-(2-fluorophenyl)propanethioamide 
• 91319-65-2 3-(2-fluorophenyl)-N-(t-butyl)propanamide 
• 91319-64-1 3-[2-(fluoro)phenyl]propionamide 

Relevant articles and documents

Cyclohexyl-Fused, Spirobiindane-Derived, Phosphine-Catalyzed Synthesis of Tricyclic ?3-Lactams and Kinetic Resolution of ?3-Substituted Allenoates

A C2-symmetric chiral phosphine catalyst, NUSIOC-Phos, which can be easily derived from cyclohexyl-fused spirobiindane, was introduced. A highly enantioselective domino process involving pyrrolidine-2,3-diones and γ-substituted allenoates catalyzed by NUSIOC-Phos has been disclosed. Diastereospecific tricyclic γ-lactams containing five contiguous stereogenic centers were obtained in high yields and with nearly perfect enantioselectivities. A kinetic resolution process of racemic γ-substituted allenoates was developed for the generation of optically enriched chiral allenoates.

Carboxy Group as a Remote and Selective Chelating Group for C?H Activation of Arenes

The first example of carboxy group assisted, remote-selective C(sp2)?H activation with a PdII catalyst has been developed and proceeds through a possible κ2 coordination of the carboxy group, thus suppressing the ortho-C?H activation through κ1 coordination. Besides meta-C?H olefination, direct meta-arylation of hydrocinnamic acid derivatives with low-cost aryl iodides has been achieved for the first time. These findings may motivate the exploration of novel reactivities of the carboxy assisted C?H activation reactions with intriguing selectivities.

Cross-coupling of remote meta -c-h bonds directed by a u-shaped template

meta-C-H arylation and methylation of 3-phenylpropanoic acid and phenolic derivatives were developed using an easily removable nitrile template. The combination of a weakly coordinating U-shaped template and mono-protected amino acid ligand was crucial fo