52166-05-9Relevant articles and documents
Rhodium-catalyzed, highly enantioselective 1,2-addition of aryl boronic acids to α-ketoesters and α-diketones using simple, chiral sulfur-olefin ligands
Zhu, Ting-Shun,Jin, Shen-Shuang,Xu, Ming-Hua
supporting information; experimental part, p. 780 - 783 (2012/02/06)
Simply the best: The title reaction has been achieved by asymmetric rhodium catalysis employing an extremely simple, chiral N-(sulfinyl)cinnamylamine ligand. A variety of highly enantioenriched, tertiary α-hydroxy carbonyl derivatives were easily accessed
Asymmetric Addition of Organometallics to Chiral Ketooxazolines. Preparation of Enantiomerically Enriched α-Hydroxy Acids
Meyers, A. I.,Slade, Joel
, p. 2785 - 2791 (2007/10/02)
Addition of Grignard and organolithium reagents to chiral α-ketooxazolines results in α-substituted α-hydroxyoxazoline derivatives which on hydrolytic removal of the chiral auxiliary groups give rise to α-substituted α-hydroxy acids in 30-87 percent enantiomeric excess (ee).Studies on the various parameters (solvents, temperature, substituents) were undertaken to reach optimum asymmetric induction.