1882-56-0

Usage

Uses

Used in Pharmaceutical Industry:
Phenyl(p-tolyl)acetic acid is used as a key intermediate in the synthesis of various drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac and indomethacin. Its chemical structure allows it to be a versatile component in the creation of medications aimed at reducing inflammation and pain.
Used in Anti-inflammatory and Analgesic Applications:
Phenyl(p-tolyl)acetic acid is used as an agent with potential anti-inflammatory and analgesic properties, making it a subject of interest for the development of treatments aimed at alleviating pain and reducing inflammation.
Used in Neurological Disorder Treatment:
Phenyl(p-tolyl)acetic acid is being investigated for its potential use in the treatment of depression and other neurological disorders, highlighting its possible role in future therapeutic interventions for such conditions.

InChI:InChI=1/C15H14O2/c1-11-7-9-13(10-8-11)14(15(16)17)12-5-3-2-4-6-12/h2-10,14H,1H3,(H,16,17)

Upstream product

• 5468-18-8 2-phenyl-3-p-tolyl-succinic acid diamide 
• 611-71-2 MANDELIC ACID 
• 108-88-3 toluene 
• 4870-65-9 2-bromophenylacetic acid 
• 532-28-5 (RS)-mandelonitrile 
• 779-14-6 p-methyl-a-phenylbenzylchloride 
• 201230-82-2 carbon monoxide 
• 102-96-5 (2-nitroethenyl)benzene 
• 7646-78-8 tin(IV) chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 1882-56-0 2-(4-methylphenyl)-2-phenylacetic acid 
• 124-38-9 carbon dioxide 
• 76981-22-1 4-methylbenzophenone hydrazone 
• 7511-88-8 2-phenyl-3-(p-tolyl)succinonitrile 

Downstream Products

• 50353-99-6 1,2-diphenyl-2-p-tolylethanone 
• 25124-94-1 phenyl-p-tolyl-acetic acid amide 
• 33142-31-3 phenyl-p-tolyl-acetic acid anilide 
• 860743-69-7 phenyl-p-tolyl-acetic acid menthyl ester 
• 98901-19-0 N-tert-butyl-2-phenyl-2-p-tolylacetamide 
• 1882-56-0 (+)-(4-methylphenyl)phenylacetic acid 
• 91-01-0 1,1-Diphenylmethanol 
• 76-84-6 triphenylmethyl alcohol 
• 519-73-3 triphenylmethane 
• 101-81-5 Diphenylmethane 
• 124-38-9 carbon dioxide 
• 23010-14-2 (4-methylphenyl)(phenyl)methyl acetate 
• 2523-39-9 3-methylfluorene 
• 1220911-32-9 2-phenyl-N-(3-phenylpropyl)-2-(p-tolyl)acetamide 

Relevant academic research and scientific papers

Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2

The first ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2 to generate important aryl acetic acids is reported. Besides aldehyde hydrazones, a variety of ketone hydrazones, which have not been successfully applied in previous umpolung reactions with other reactive electrophiles, also show high reactivity and selectivity under mild conditions. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and offers easy derivation of important structures, including bioactive felbinac and adiphenine. Computational studies reveal that this umpolung reaction proceeds through the generation of a Ru-nitrenoid followed by concerted [4 + 2] cycloaddition with CO2.

Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Cross-electrophile couplings between two electrophiles are powerful and economic methods to generate C-C bonds in the presence of stoichiometric external reductants. Herein, we report a novel strategy to realize the first external-reductant-free cross-electrophile coupling via visible-light photoredox catalysis. A variety of tetraalkyl ammonium salts, bearing primary, secondary, and tertiary C-N bonds, undergo selective couplings with aldehydes/ketone and CO2. Notably, the in situ generated byproduct, trimethylamine, is efficiently utilized as the electron donor. Moreover, this protocol exhibits mild reaction conditions, low catalyst loading, broad substrate scope, good functional group tolerance, and facile scalability. Mechanistic studies indicate that benzyl radicals and anions might be generated as the key intermediates via photocatalysis, providing a new direction for cross-electrophile couplings.

Highly para-Selective C?H Alkylation of Benzene Derivatives with 2,2,2-Trifluoroethyl α-Aryl-α-Diazoesters

Compared to the most popular directing-group-assisted strategy, the “undirected” strategy for C?H bond functionalization represents a more flexible but more challenging approach. Reported herein is a gold-catalyzed highly site-selective C(sp2)?H alkylation of unactivated arenes with 2,2,2-trifluoroethyl α-aryl-α-diazoesters. This protocol demonstrates that high site-selective C?H bond functionalization can be achieved without the assistance of a directing group. In this transformation, both the gold catalyst and trifluoroethyl group on the ester of the diazo compound play vital roles for achieving the chemo- and regioselectivity.

N-SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The present invention relates to N-substituted heterocyclic derivatives of formula: STR1 processes for their preparation, and pharmaceutical compositions which contain them. The compounds according to the invention are non-peptide compounds which oppose the action of angiotensin II. The compounds according to the invention are thus useful in the treatment of cardiovascular disorders such as hypertension and heart failure.

COBALT-CATALYZED SYNTHESIS OF α-ARYLPROPIONIC AND DIARYLACETIC ACIDS

The cobalt-catalyzed carbonylation of ArCH(R)X (R=CH3, C6H5; X=Cl, Br) in alcoholic solvents under atmospheric pressure of CO is reported.Selective, high yield synthesis of the corresponding acids ArCH(R)COOH can be achieved within a very narrow range of experimental conditions by controlling kinetically the reversible interconversion of intermediate aryl and alkylcobalt complexes.The important roles of the base and of the alcoholic medium are briefly discussed.