5217-90-3Relevant academic research and scientific papers
Synthesis and binding affinity to human α and β estrogen receptors of various 7-hydroxycoumarins substituted at 4- and 3,4- positions
Kirkiacharian, Serge,Lormier, Anh Tuan,Chidiack, Henri,Bouchoux, Franoise,Crde, Evelyne
, p. 981 - 986 (2004)
The study of the relative binding affinity (RBA) to the human α and β estrogen receptors (ERs) of various 7-hydroxycoumarins substituted at 4- and 3,4- positions is weak and lacks in selectivity for both ERα and ERβ. The 4-(4-hydroxyphenyl)-7-hydroxycoumarin shows a weak RBA to ERβ and 3,4-diphenyl-7-hydroxycoumarin presents a stronger RBA to ERα than ERβ.
