52181-18-7Relevant academic research and scientific papers
Alkyl keto-amide, amidoxime compound thereof, and preparation and application of compound
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Paragraph 0046, (2019/01/23)
The invention relates to alkyl keto-amide, an amidoxime compound thereof, and preparation and application of the compound. The alkyl keto-amide compound and a derivative thereof can be applied to metal palladium catalyzed C-H bond fluoridation, better rea
Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles
Wang, Dong,Li, Linna,Feng, Hairong,Sun, Hua,Almeida-Veloso, Fabrice,Charavin, Marine,Yu, Peng,Désaubry, Laurent
supporting information, p. 2775 - 2780 (2018/06/27)
An efficient synthesis of fully substituted 2,3-dihydropyrroles has been achieved in one step through the three-component reaction of amines, aromatic aldehydes and α-ketoamides. This atom-economical and catalyst-free reaction is highly stereoselective and generates underexplored heterocycles in a single step. These compounds were examined in an enzymatic assay that led to the identification of potent α-glucosidase inhibitors, thereby demonstrating the utility of this novel methodology in medicinal chemistry.
Synthesis of some novel pyrrolyl hydrazone derivatives as an antitubercular agents
Joshi, Shrinivas D.,Tigadi, Nageshwar,Kumar, Devendra,Dixit, Sheshagiri R.,Jangade
, p. 237 - 241 (2019/01/18)
Over the past decades, several anti-tuberculosis (anti-TB) drugs have been developed but drugresistance issue is still increasing. Thus there is a demand to develop new anti-TB drugs that are active against both acute and chronic growth phases of mycobacterium. Herein we have synthesized a novel series of pyrrolyl hydrazone derivatives and characterized by using spectral data. The synthesized compounds have been evaluated for their in vitro antitubercular activity using Microplate Alamar Blue Assay (MABA) method against Mycobacterium tuberculosis H37Rv strain. Compounds 5e, 5c, 6a and 6b have shown good antitubercular activity at MIC value of 6.25, 12.5, 12.5 and 12.5 μg/ml, respectively.
Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands
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, (2008/06/13)
The present invention relates to novel indolin-2-one derivatives of formula: to the preparation and to the pharmaceutical compositions comprising them. These compounds have an affinity for oxytocin receptors.
