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52189-90-9

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52189-90-9 Usage

Preparation

Preparation by Fries rearrangement, of 4-acetoxy-4′-hydroxybiphenyl with aluminium chloride without solvent for 6 h at 168–170° (57%); of 4,4′-diacetoxybiphenyl with aluminium chloride in tetrachloroethane for 6 h at 160° (34%).

Check Digit Verification of cas no

The CAS Registry Mumber 52189-90-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,1,8 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 52189-90:
(7*5)+(6*2)+(5*1)+(4*8)+(3*9)+(2*9)+(1*0)=129
129 % 10 = 9
So 52189-90-9 is a valid CAS Registry Number.

52189-90-9Downstream Products

52189-90-9Relevant articles and documents

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

Paterni, Ilaria,Bertini, Simone,Granchi, Carlotta,Tuccinardi, Tiziano,Macchia, Marco,Martinelli, Adriano,Caligiuri, Isabella,Toffoli, Giuseppe,Rizzolio, Flavio,Carlson, Kathryn E.,Katzenellenbogen, Benita S.,Katzenellenbogen, John A.,Minutolo, Filippo

, p. 1184 - 1194 (2015)

Estrogen receptor β (ERβ) selective agonists are considered potential therapeutic agents for a variety of pathological conditions, including several types of cancer. Their development is particularly challenging, since differences in the ligand binding cavities of the two ER subtypes α and β are minimal. We have carried out a rational design of new salicylketoxime derivatives which display unprecedentedly high levels of ERβ selectivity for this class of compounds, both in binding affinity and in cell-based functional assays. An endogenous gene expression assay was used to further characterize the pharmacological action of these compounds. Finally, these ERβ-selective agonists were found to inhibit proliferation of a glioma cell line in vitro. Most importantly, one of these compounds also proved to be active in an in vivo xenograft model of human glioma, thus demonstrating the high potential of this type of compounds against this devastating disease.

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