5219-59-0

Upstream product

• 46922-55-8 (R)-N-benzyl-1-phenoxypropan-2-amine 
• 34238-86-3 C₁₈H₂₃NO₂ 
• 122-60-1 Phenyl glycidyl ether 
• 42060-32-2 N-benzyl-2-nitrobenzenesulfonamide 
• 71031-03-3 (R)-phenyl glycidyl ether 
• 130879-97-9 (S)-1-Phenoxypropan-2-ol 
• 108-95-2 phenol 
• 100-46-9 benzylamine 
• 101-45-1 N-(phenoxyisopropyl)-N-benzyl ethanolamine 

Relevant academic research and scientific papers

A PROCESS FOR THE PREPARATION OF PHENOXYBENZAMINE

The present invention provides a process for the preparation of N-phenoxyisopropyl ethanolamine of Formula (II) and its conversion to Phenoxybenzamine of Formula (I) or pharmaceutically acceptable salts thereof.

COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING SALT SENSITIVITY OF BLOOD PRESSURE

To characterize the urinary exosome miRNome, microarrays were used to identify the miRNA spectrum present within urinary exosomes from ten individuals that were previously classified for their salt sensitivity status. The present application discloses distinct patterns of selected exosomal miRNA expression that were different between salt-sensitive (SS), salt-resistant (SR), and inverse salt-sensitive (ISS) individuals. These miRNAs can be useful as biomarkers either individually or as panels comprising multiple miRNAs. The present invention provides compositions and methods for identifying, diagnosing, monitoring, and treating subjects with salt sensitivity of blood pressure. The applications discloses panels of miRNAs useful for comparing profiles, and in some cases one or more of the miRNAs in a panel can be used. The miRNAs useful for distinguishing SS and SR or ISS and SR subjects. One or more of the 45 miRNAs can be used. Some of the miRNAs have not been previously reported to be circulating. See those miRNAs with asterisks in FIG. 1 and below. The present invention encompasses the use of one or more of these markers for identifying and diagnosing SR, SS, and ISS subjects.

A facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method

A practical and highly efficient enantioselective synthesis of (R)-phenoxybenzamine hydrochloride has been described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and source of chirality.