52191-14-7Relevant academic research and scientific papers
Sodium Bromide-Catalyzed Oxidation of Secondary Benzylic Alcohols Using Aqueous Hydrogen Peroxide as Terminal Oxidant
Komagawa, Hiromi,Maejima, Yukako,Nagano, Takashi
supporting information, p. 789 - 793 (2016/03/09)
A halide salt, hydroperoxide and AcOH catalyst system was applied to the oxidation of secondary benzylic alcohols. This simple system can be applied to a variety of secondary benzylic alcohols and scaled up for gram-scale preparation. High secondary benzylic alcohol selectivity of the present method is demonstrated in hydroxyketone synthesis. Based on several experimental results, a catalytic cycle for our oxidation is proposed.
COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION
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Page/Page column 77-78, (2012/02/01)
Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.
Structure-based design of thienobenzoxepin inhibitors of PI3-kinase
Staben, Steven T.,Siu, Michael,Goldsmith, Richard,Olivero, Alan G.,Do, Steven,Burdick, Daniel J.,Heffron, Timothy P.,Dotson, Jenna,Sutherlin, Daniel P.,Zhu, Bing-Yan,Tsui, Vickie,Le, Hoa,Lee, Leslie,Lesnick, John,Lewis, Cristina,Murray, Jeremy M.,Nonomiya, Jim,Pang, Jodie,Prior, Wei Wei,Salphati, Laurent,Rouge, Lionel,Sampath, Deepak,Sideris, Steve,Wiesmann, Christian,Wu, Ping
scheme or table, p. 4054 - 4058 (2011/08/06)
Starting from thienobenzopyran HTS hit 1, co-crystallization, molecular modeling and metabolic analysis were used to design potent and metabolically stable inhibitors of PI3-kinase. Compound 15 demonstrated PI3K pathway suppression in a mouse MCF7 xenogra
Cyclization of 2-(2-bromoethoxy)-acetophenones and 5-(ω-haloalkoxy)- 1,5-dihydro-2H-pyrrol-2-ones - Formation of five- to eight-membered oxygen-containing heterocycles via intramolecular alkylation
Nikitin, Kirill V.,Andryukhova, Nonna P.
, p. 571 - 578 (2007/10/03)
Under basic conditions (lithium diisopropylamide or sodium hydride in THF) 2-(2-bromoethoxy)-acetophenones were transformed to 3,4-dihydro[1]benzoxepin- 5(2H)-ones (homochromanones) in high yields. The preparation of novel tetrahydropyrano[2,3-b]pyrrol-6(
An efficient synthetic strategy for geometrically pure symmetrical and unsymmetrical hydroxystilbenes via McMurry coupling
Mayekar, Narayan V.,Chattopadhyay, Subrata,Nayak, Sandip K.
, p. 2041 - 2046 (2007/10/03)
Intramolecular reductive deoxygenation of ethylenedioxy tethered symmetrical and unsymmetrical aromatic bis(carbonyl) ethers with the low-valent titanium (LVT) reagent (TiCl4-Zn-THF) yielded chromatographically separable E/Z-isomers of corresponding cyclic stilbenes which were further dealkylated to obtain geometrically pure hydroxystilbenes. The intramolecular McMurry coupling of the tethered bis(carbonyl) ethers with TiCl 3-Li-THF, on the other hand, directly provided both symmetrical and unsymmetrical phenanthrenes via in situ dealkoxylation of the phenol function. This is the first report of the synthesis of unsymmetrical phenanthrenes by the LVT route.
