521964-59-0Relevant academic research and scientific papers
Facile preparation of tert-butyl 1-tert-butoxycarbonylaminocyclopent-3- enecarboxylate from inexpensive starting materials
Larionov, Oleg V.,Kozhushkov, Sergei I.,De Meijere, Armin
, p. 158 - 160 (2005)
1,5-C,C-Cycloalkylation of tert-butyl acetoacetate (1) with cis-1,4-dichloro-2-butene (2) followed by the haloform reaction of the product in NaOH solution and subsequent Curtius degradation in tert-butyl alcohol furnished tert-butyl 1-tert-butoxycarbonyl
Design, development, and scale-up of a selective meso-epoxide desymmetrization process
Varie, David L.,Beck, Christopher,Borders, Sandra K.,Brady, Molly D.,Cronin, Jason S.,Ditsworth, Tracy K.,Hay, David A.,Hoard, David W.,Hoying, Richard C.,Linder, Ryan J.,Miller, Richard D.,Moher, Eric D.,Remacle, Jacob R.,Rieck III, John A.,Anderson, David D.,Dodson, Paul N.,Forst, Mindy B.,Pierson, Duane A.,Turpin, Joseph A.
, p. 546 - 559 (2012/12/31)
A pilot-plant scale desymmetrization of the cyclic meso-epoxide 4b, using a chiral lithium amide prepared from symmetrical diamine 17, was designed and implemented to provide allylic alcohol 3b in high yield and greater than 99% ee. This chiral alcohol was converted to ketone 2b, a key intermediate in a new asymmetric synthesis of LY459477. Chiral diamine 17 was prepared from a readily available chiral precursor, (R)-α-methylbenzylamine, and could be recovered from the reaction mixture and reused. Studies performed to probe the mechanism of the rearrangement reaction of epoxide 4b showed that diamine 17 provided an optimal combination of selectivity and scaleability for this process.
PRODRUGS OF EXCITATORY AMINO ACIDS
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Page 68-71, (2008/06/13)
This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorder
