52201-28-2

Basic information

• Product Name: Pyrrolidine, 1-(1-methyl-2-phenylethenyl)-
• CAS NO: 52201-28-2
• Molecular Formula: C13H17N
• Molecular Weight: 187.285
• Mol File: 52201-28-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-(1-methyl-2-phenylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(1-methyl-2-phenylethenyl)-(52201-28-2)
• EPA Substance Registry System: Pyrrolidine, 1-(1-methyl-2-phenylethenyl)-(52201-28-2)

Safety Data

• Hazardous Substances Data: 52201-28-2(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 103-79-7 1-phenyl-acetone 
• 673-32-5 1-Phenylprop-1-yne 

Downstream Products

• 61282-84-6 4,5,5,5-Tetrafluor-3-phenylpent-3-en-2-on 
• 857259-65-5 5-methyl-3,4-diphenyl-5-(pyrrolidin-1-yl)-4,5-dihydroisoxazole 
• 37928-17-9 5-methyl-3,4-diphenyl isoxazole 
• 21120-43-4 1-phenyl-1-fluoro-2-propanone 
• 181695-72-7 valdecoxib 
• 509074-26-4 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonyl chloride 
• 1373038-60-8 C₃₂H₂₅N₃O₆S₂ 
• 181696-35-5 5-methyl-3-phenyl-4-(4-sulfophenyl)isoxazole 
• 1373038-63-1 C₁₆H₁₁Cl₂NO₅S₂ 
• 1373038-62-0 C₁₆H₁₂ClNO₃S 
• 1373038-58-4 C₁₆H₁₄N₂O₃S 
• 1373038-56-2 3-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide 
• 1373038-57-3 C₁₆H₁₂ClNO₃S 
• 1373038-61-9 C₂₀H₂₂N₂O 

Relevant articles and documents

Method for preparing parecoxib sodium key intermediates

The invention relates to a method for preparing parecoxib sodium key intermediates, and belongs to the field of medicine synthesis. The method for preparing the parecoxib sodium key intermediates includes steps of firstly, preparing 1-(1-methyl-2-styrene)-pyrrolidine (a compound I); secondly, preparing 5-methyl-3, 4-diphenyl-5-(pyrrolidine-1-base)-4, 5-dihydro-isoxazole (a compound II); thirdly, preparing a crude product of 5-methyl-3, 4-diphenyl isoxazole (a compound III); fourthly, refining a crude product of 5-methyl-3, 4-diphenyl-5-isoxazole (a compound III). The shortcomings of existing synthesis methods can be overcome by the aid of the method. The method for preparing the parecoxib sodium key intermediates has the advantages of mild reaction conditions, inexpensive and easily available raw materials, simplicity in after-treatment operation, short production cycle and high product purity and yield. Besides, the novel method is provided for preparing the parecoxib sodium key intermediates.

Application of [3+2]-cycloaddition in the synthesis of valdecoxib

A large scale synthesis of valdecoxib 1 is described. Our work features potential application of [3+2]-dipolar cycloaddition involving enamine and in situ-generated nitrile oxide derivatives. Dr. Reddy's Laboratories Ltd.