52221-98-4

Upstream product

• 95-94-3 1,2,4,5-tetrachlorobenzene 
• 50-00-0 formaldehyd 

Downstream Products

• 4681-19-0 2,3,5,6-tetrachlorobenzyl chloride 
• 52221-94-0 2,3,5,6-Tetrachlor-N,N-dimethylbenzylamin 
• 52221-97-3 α-Brom-2,3,5,6-tetrachlortoluol 

Relevant academic research and scientific papers

PIEZO1 AGONISTS FOR THE PROMOTION OF BONE FORMATION

Disclosed herein are Piezo 1 agonists. Also disclosed herein are methods of stimulating tissue anabolism in a subject comprising administering an effective amount of a Piezo 1 agonist and methods for chemically mimicking mechanical stimulation of a cell expressing Piezo 1 comprising contacting a cell expressing Piezo1 with an effective amount of a Piezo 1 agonist.

Method for producing cyclopropanecarboxylates

There is provided a method for producing a cyclopropanecarboxylate of formula (1): 1which comprises contacting a cyclopropanecarboxylate of formula (2): 2with a monohydroxy compound of formula (3):R7OH??(3)in the presence of a lithium compound of formula (4):R8OLi??(4),wherein R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, or a substituted or unsubstituted aryl group; R6 represents an alkyl group having 1 to 10 carbon atoms or a substituted or unsubstituted phenyl group; R7 and R8 do not simultaneously represent the same and each independently represent a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group.