4681-19-0Relevant academic research and scientific papers
PIEZO1 AGONISTS FOR THE PROMOTION OF BONE FORMATION
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, (2021/04/10)
Disclosed herein are Piezo 1 agonists. Also disclosed herein are methods of stimulating tissue anabolism in a subject comprising administering an effective amount of a Piezo 1 agonist and methods for chemically mimicking mechanical stimulation of a cell expressing Piezo 1 comprising contacting a cell expressing Piezo1 with an effective amount of a Piezo 1 agonist.
Method for preparing 2, 3, 5, 6-tetrachlorobenzonitrile, special catalyst and preparation method thereof
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Paragraph 0024-0031, (2020/09/16)
The invention discloses a method for preparing 2, 3, 5, 6-tetrachlorobenzonitrile, which comprises the following steps: by using 1, 2, 4, 5-tetrachlorobenzene as a raw material, obtaining 2, 3, 5, 6-tetrachlorobenzyl chloride under the action of a special chloromethylation catalyst, and obtaining 2, 3, 5, 6-tetrachlorobenzonitrile under the action of a special ammonia oxidation catalyst. The invention further discloses a special catalyst for preparing 2, 3, 5, 6-tetrachlorobenzonitrile and the preparation method. The special chloromethylation catalyst and the special ammoxidation catalyst havethe advantages of high activity, high product yield, good selectivity, high product purity, long service life and simple process; and the preparation method has the advantages of short reaction route, low reaction temperature, high yield and high selectivity.
