52249-83-9

Upstream product

• 52800-47-2 3-(benzyloxy)benzene-1,2-diol 
• 77-78-1 dimethyl sulfate 
• 103214-99-9 2-ethoxy4-hydroxy-1,3-benzodioxol 
• 5150-42-5 2,3-dimethoxyphenol 
• 100-39-0 benzyl bromide 
• 87-66-1 2-hydroxyresorcinol 
• 100-44-7 benzyl chloride 
• 103215-00-5 4-(benzyloxy)-2-ethoxybenzo[d][1,3]dioxole 

Downstream Products

• 3117-02-0 2,3-dimethoxy-1,4-benzoquinone 
• 19587-73-6 2.3-Dimethoxy-4-benzyloxy-benzylalkohol 
• 69471-04-1 4-benzyloxy-2,3-dimethoxybenzaldehyde 
• 913985-89-4 N-[2-(4-benzyloxy-2,3-dimethoxy-phenyl)-ethyl]-acetamide 
• 770686-91-4 4-benzyloxy-2,3-dimethoxyphenethylamine 
• 913985-88-3 4-bromo-2,3-dimethoxy-1-benzyloxybenzene 

Relevant academic research and scientific papers

Exploring the Reactivity of α-Lithiated Aryl Benzyl Ethers: Inhibition of the [1,2]-Wittig Rearrangement and the Mechanistic Proposal Revisited

By carefully controlling the reaction temperature, treatment of aryl benzyl ethers with tBuLi selectively leads to α-lithiation, generating stable organolithiums that can be directly trapped with a variety of selected electrophiles, before they can undergo the expected [1,2]-Wittig rearrangement. This rearrangement has been deeply studied, both experimentally and computationally, with aryl α-lithiated benzyl ethers bearing different substituents at the aryl ring. The obtained results support the competence of a concerted anionic intramolecular addition/elimination sequence and a radical dissociation/recombination sequence for explaining the tendency of migration for aryl groups. The more favored rearrangements are found for substrates with electron-poor aryl groups that favor the anionic pathway.

Syntheses and anti-inflammatory activity of natural 1,3-diarylpropenes

First syntheses of five natural 1,3-diarylpropenes (cinnamylphenols) 2-4, 7, and 8 along with synthesis of two other natural 1,3-diarylpropenes 1 and 5 and E-isomer of mucronulastyrene (6) were achieved by Friedel- Crafts alkylation as a key step. Subsequ

Chinone von Benzo- und Dibenzokronenethern

The preparation of the 1,4-quinones of benzocrown-5 (1), benzocrown-6 (2), and dibenzocrown-6 (3) and their quinols is described.The quinones are obtained by Fremy salt oxidation of the corresponding 3-hydroxybenzo-crown ethers which are readily accessible by a double protective group synthesis from 1,2,3-trihydroxybenzene.The synthetic pathway also provides a general high yield preparation of 2,3-dialkoxy-1,4-benzoquinones.The new crown ethers are characterised by 1H- and 13C-N.M.R. as well as U.V. spectroscopy.Non-aqueous redox potentials aredetermined by cyclic voltammetry.Crystalline complexes of 1 and 2 with various ammonium, alkali, and alkaline earth cations are also described.