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Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 52249-88-4 Structure
  • Basic information

    1. Product Name: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-
    2. Synonyms: Ethanone,1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl];
    3. CAS NO:52249-88-4
    4. Molecular Formula: C16H16O4
    5. Molecular Weight: 272.301
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 52249-88-4.mol
  • Chemical Properties

    1. Melting Point: 151°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-(52249-88-4)
    11. EPA Substance Registry System: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-(52249-88-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 52249-88-4(Hazardous Substances Data)

52249-88-4 Usage

Preparation

Preparation by reaction of benzyl bromide on 2,5-di-hydroxy-4-methoxyacetophenone with potassium carbonate in boiling acetone (67%).

Check Digit Verification of cas no

The CAS Registry Mumber 52249-88-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,2,4 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52249-88:
(7*5)+(6*2)+(5*2)+(4*4)+(3*9)+(2*8)+(1*8)=124
124 % 10 = 4
So 52249-88-4 is a valid CAS Registry Number.

52249-88-4Relevant articles and documents

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

Hayakawa, Ichiro,Shioda, Shuya,Chinen, Takumi,Hatanaka, Taisei,Ebisu, Haruna,Sakakura, Akira,Usui, Takeo,Kigoshi, Hideo

, p. 5639 - 5645 (2016/10/24)

We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50?=?2.1?μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiments of O6-benzyl glaziovianin A and revealed that O6-benzyl glaziovianin A binds to the colchicine binding site with high affinity. It is interesting that glaziovianin A derivatives change their mode of action in benzylation at the O6(α,β-tubulin inhibitor) or O7(γ-tubulin-specific inhibitor) position.

Micro tube polymn. inhibitor (by machine translation)

-

Paragraph 0057-0058; 0062-0063, (2018/10/10)

PROBLEM TO BE SOLVED: micro tube polymn. inhibitory activity, as of cytokinetic promisingness. SOLUTION: compd. eq. (I) or pharmaceutically acceptable salt thereof is represented. (A cycloalkyl group, an aryl group, an alkyl or heterocyclyl group; R1, an alkenyl group, an alkynyl group or aryl alkyl group; m is an integer) selected drawing 1-8:no (by machine translation)

Studies on the metabolism of propafenone. 1st comm.: Synthesis and chromatographic/mass spectrometric properties of the labelled compound and of the reference substances

Hege,Weymann,Lietz

, p. 843 - 849 (2007/10/02)

The synthesis of 14C-propafenone and 2H-propafenone (propafenone: 2-(2'-hydroxy-3'-propylamino-propoxy)-ω-phenyl-propiophenone hydrochloride) and some reference compounds is described. The thin-layer chromatographic, high-performance liquid and gas chromatographic properties of the substances are described. Propafenone and the reference substances were studied by mass spectrometry and compared with each other, with respect to structural elucidation of the metabolites. The chromatographic and mass spectrometric data (key ions) enables the metabolites of propafenone to be identified in biological material.

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