522622-93-1

Basic information

• Product Name: 2-amino-6-O-[(3'-hydroxymethyl)benzyloxy]-9-benzylpurine
• Synonyms: 2-amino-6-O-[(3'-hydroxymethyl)benzyloxy]-9-benzylpurine
• CAS NO: 522622-93-1
• Molecular Weight: 361.403
• Mol File: 522622-93-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-6-O-[(3'-hydroxymethyl)benzyloxy]-9-benzylpurine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-O-[(3'-hydroxymethyl)benzyloxy]-9-benzylpurine(522622-93-1)
• EPA Substance Registry System: 2-amino-6-O-[(3'-hydroxymethyl)benzyloxy]-9-benzylpurine(522622-93-1)

Safety Data

• Hazardous Substances Data: 522622-93-1(Hazardous Substances Data)

Upstream product

• 10310-21-1 2-Amino-6-chloropurin 
• 6336-42-1 2-amino-9-benzyl-6-chloro-9H-purine 
• 100-39-0 benzyl bromide 
• 626-18-6 1,3-dimethanol benzene 

Relevant articles and documents

Synthesis of radiolabeled O6-benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase

Novel radiolabeled O6-benzylguanine derivatives, 2-amino-6-O-[11C]-[(methoxymethyl)benzyloxy]-9-benzyl purines ([11C]p-O6AMBP, 1a; [11C]m-O6-AMBP, 1b; [11C]o-O6-AMBP, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agents for the DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT). The appropriate precursors for radiolabeling were obtained in three steps from starting material 2-amino-6-chloropurine with moderate to excellent chemical yields. Tracers were prepared by O-[11C]methylation of hydroxymethyl precursors using [11C]methyl triflate. Pure target compounds were isolated by solid-phase extraction (SPE) purification procedure in 45-60% radiochemical yields (decay corrected to the end of bombardment), and a synthesis time of 20-25 min. Copyright