522651-96-3

Usage

General Description

2-(4-Bromo-phenyl)-imidazo [1,2-a]pyridine-3-carboxaldehyde is a chemical compound with a molecular formula C14H9BrN2O. It is a heterocyclic compound containing an imidazo[1,2-a]pyridine core with a 4-bromo-phenyl group attached to it, and a carboxaldehyde functional group at position 3. 2-(4-BROMO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE has potential applications in the field of medicinal chemistry and drug discovery, as it may exhibit biological activity due to its unique structure. Further research and study are needed to fully understand the properties and potential uses of 2-(4-Bromo-phenyl)-imidazo[1,2-a]pyridine-3-carboxaldehyde.

Upstream product

• 504-29-0 2-aminopyridine 
• 1314079-06-5 N-(1-(4-bromophenyl)allyl)-2-aminopyridine 
• 1122-91-4 4-bromo-benzaldehyde 
• 138023-09-3 N-(4-bromobenzylidene)pyridin-2-amine 
• 34658-66-7 2-(4-bromophenyl)imidazo[1,2-a]pyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 99-90-1 para-bromoacetophenone 
• 99-73-0 para-bromophenacyl bromide 
• 49678-04-8 4-bromocinnamaldeyde 

Downstream Products

• 1176446-88-0 (2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl)methanol 
• 1417910-20-3 C₁₄H₁₀BrN₅ 
• 1417910-27-0 2-(4-bromophenyl)-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 1417910-28-1 2-(4-bromophenyl)-3-((4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 
• 1417910-29-2 2-(4-bromophenyl)-3-((4-p-tolyl-1H-1,2,3-triazol-1-yl)methyl)-1H-imidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

SUBSTITUTED DIAZAHETERO-BICYCLIC COMPOUNDS AND THEIR USE

The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to th

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is

2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS BLOCKERS OF TASK-1 AND TASK-2 CHANNELS, FOR THE TREATMENT OF SLEEP-RELATED BREATHING DISORDERS

The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for prepa

Novel method for one-step construction of substituted 2-phenylimidazo[1,2-a]pyridine-3-aldehyde by using DMF (N,N-dimethylformamide) as formylation reagent

The invention discloses a novel method for one-step construction of substituted 2-phenylimidazo[1,2-a]pyridine-3-aldehyde by using DMF (N,N-dimethylformamide) as a formylation reagent. According to the method, substituted 2-phenylimidazo[1,2-a]pyridine is

SUBSTITUTED PERHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND THE USE OF SAME

The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention

Synthesis and antimicrobial activity of novel imidazo[1,2-a]pyridinopyrimidine-2,4,6(1H,3H,5H)-triones and thioxopyrimidine-4,6(1H,5H)diones

A novel series of imidazo[1,2-a]pyridinopyrimidine-2,4,6(1H,3H,5H)-triones and thioxopyrimidine-4,6(1H,5H)diones were synthesized via multistep synthesis starting from 2-aminopyridine on cyclisation with phenacyl bromide followed by Vilsmeier-Haack and Kn

One-pot multicomponent synthesis of novel substituted imidazo[1,2-a]pyridine incorporated thiazolyl coumarins and their antimicrobial activity

A series of novel substituted imidazo[1,2-a]pyridine incorporated thiazolyl coumarin derivatives (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o, 4p, 4q, 4r, 4s, 4t) were synthesized in good yields via one-pot multicomponent condensation of su

Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors

A new series of DPP-4 inhibitors with imidazo[1,2-a]pyridine scaffold were designed by exploiting scaffold hopping strategy and docking study. Based on docking binding model, structural modifications of 2-benzene ring and pyridine moieties of compound 5a led to the identification of compound 5d with 2, 4-dichlorophenyl group at the 2-position as a potent (IC50 = 0.13 μm), selective (DPP-8/DPP-4 = 215 and DPP-9/DPP-4 = 192) and in vivo efficacious DPP-4 inhibitor. Further, molecular docking revealed that compound 5d could retain key binding features of DPP-4 with the pyridine moiety of imidazo[1,2-a]pyridine ring providing an additional π-π interaction with Phe357 of DPP-4. Compound 5d might be a promising lead for further development of novel DPP-4 inhibitor treating T2DM.

CuBr catalyzed aerobic oxidative coupling of 2-aminopyridines with cinnamaldehydes: direct access to 3-formyl-2-phenyl-imidazo[1,2-a]pyridines

Copper bromide catalyzed aerobic oxidative coupling of 2-aminopyridines with cinnamaldehydes directly led to the formation of 3-formyl-2-phenyl-imidazo[1,2-a]pyridines. The quantum chemical calculations were performed to trace the reaction mechanism and g

Copper-catalyzed intramolecular dehydrogenative cyclization: Direct access to sensitive formyl-substituted imidazo[1,2-a]pyridines

A direct method for the synthesis of formyl-substituted imidazo[1,2-a]pyridines was achieved easily from cyclization of aminopyridines and cinnamaldehydes via copper catalysis. This oxidative cyclization process involved direct C-H bond functionalization, and C-C/C-N bond formation. In this transformation, the sensitive aldehyde group was preserved under oxidative conditions.