522653-99-2

Basic information

• Product Name: 4-(hydroxy-2,2-dimethylpropyl)-benzonitrile
• Synonyms: 4-(hydroxy-2,2-dimethylpropyl)-benzonitrile
• CAS NO: 522653-99-2
• Molecular Weight: 189.257
• Mol File: 522653-99-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(hydroxy-2,2-dimethylpropyl)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(hydroxy-2,2-dimethylpropyl)-benzonitrile(522653-99-2)
• EPA Substance Registry System: 4-(hydroxy-2,2-dimethylpropyl)-benzonitrile(522653-99-2)

Safety Data

• Hazardous Substances Data: 522653-99-2(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 30314-45-5 1-(4-bromophenyl)-2,2-dimethylpropan-1-one 
• 106-37-6 1.4-dibromobenzene 
• 558-17-8 tert-Butyl iodide 
• 105-07-7 4-cyanobenzaldehyde 
• 150009-08-8 1-(4-cyanophenyl)-2,2-dimethyl-1-propanone 

Downstream Products

• 120136-26-7 3-Nitro-benzenesulfonic acid 1-(4-cyano-phenyl)-2,2-dimethyl-propyl ester 

Relevant articles and documents

The Barbier - Grignard-type carbonyl alkylation using unactivated alkyl halides in water

The aqueous Barbier-Grignard-type alkylation of aldehydes with unactivated alkyl iodides and bromides was developed. By using a combination of zinc and cuprous iodide, catalyzed by indium(I) chloride, we successfully added tertiary, secondary, and primary alkyl halides to various aromatic aldehydes in 0.07 M aqueous Na2C2O4. A mechanistic rationale for the success of the reaction has been proposed. Copyright