52294-86-7

Upstream product

• 54660-80-9 6-amino-1,3-dimethyl-5-formyluracil 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 70424-96-3 methyl 6-amino-1,3-dimethyluracil-5-dithiocarboxylate 
• 75-05-8 acetonitrile 
• 36980-91-3 1,3-dimethyl-5-cyanouracil 
• 90254-46-9 7-amino-6-cyano-1,3-dimethyl-5-methylthiopyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 181465-38-3 6-amino-1,3-dimethyl-5-thioformyluracil 

Relevant academic research and scientific papers

Bronchodilating pyrido?2,3-d!pyrimidine derivatives

A rapid-acting remedy for asthma having a bronchodilating action contains at least one pyrido?2,3-d!pyrimidine derivative represented by the general formula (A) or pharmaceutically acceptable salts or metal complexes thereof as an effective component: STR1 wherein R1 and R2 are the same or different and each of R1 and R2 is hydrogen, alkyl or benzyl; R3 is hydrogen, hydroxyl, dialkylaminomethyleneamino or --NH--X; X is hydrogen, alkyl, alkenyl, hydroxyl, amino, hydroxyalkyl, benzyl or acyl; R4 is hydrogen, alkyl, halogen, nitro, amino, hydroxyl, benzyloxy, cyano, carboxyl, alkoxycarbonyl, alkoxysulfonyl, aminosulfonyl, dialkylaminosulfonyl or sulfo; and R5 is hydrogen, alkyl or amino. The rapid-acting remedy for bronchial asthma is capable of relieving the symptom of laboring breath at the onset of asthma due to its excellent bronchodilating action. It can be used as a therapy not only for allergic asthma but also for various bronchial asthmas such as endogenous asthma, exogenous asthma and dust asthma.

Carbon transfer reactions of functionalized oxazolidines and their open chain enamine tautomers to enamine nucleophiles. A facile synthesis of substituted pyridines and ring annulated derivatives

Oxazolidines substituted at C-2 with -CH2-EW(-CO-, etc.) and capable of existing as ring-chain (enamine) tautomers react with cyclic, acyclic and heterocyclic enamine derivatives in a 1:1 stoi-chiometric manner to provide a versatile synthesis of substituted pyridines and their ring annulated derivatives.

Reactivities of 6-amino-1,3-dimethyl-5-thioformyluracil toward nucleophiles and its application to synthesis of pyrido[2,3-d]pyrimidines

The reaction of the 5-thioformyluracil 1 with phenylhydrazine and various amines readily afforded the hydrazone 3a and Schiff bases 3b-d, respectively. Further, carbanions and Wittig reagents reacted with 1 to give pyrido[2,3-d]pyrimidines 4 and 9. The co

5-substituted pyrido[2,3-d]pyrimidine-2,4-diones

The present invention relates to a novel pyrido[2,3-d]pyrimidine derivative having the formula (I): STR1 wherein each of R1 and R2, which may be the same or different, is a lower alkyl group; and each of R3 and R4, which may be the same or different, is hydrogen, halogen, hydroxy, nitro, amino, hydroxyamino, hydrazino, azido, a lower alkenylamino group or a lower alkylamino group which may optionally have hydroxy; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

Reaction of 6-Aminouracils with Ketenethioacetals

Reaction of ketenethioacetals with 6-aminouracils (1a: R1=R2=Me, 1b: R1=Ph, R2=H) in the presence of potassium carbonate followed by cyclization unde