52294-86-7

Upstream product

• 90254-46-9 7-amino-6-cyano-1,3-dimethyl-5-methylthiopyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 75-05-8 acetonitrile 
• 36980-91-3 1,3-dimethyl-5-cyanouracil 
• 54660-80-9 6-amino-1,3-dimethyl-5-formyluracil 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 181465-38-3 6-amino-1,3-dimethyl-5-thioformyluracil 
• 70424-96-3 methyl 6-amino-1,3-dimethyluracil-5-dithiocarboxylate 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 

Relevant academic research and scientific papers

Carbon transfer reactions of functionalized oxazolidines and their open chain enamine tautomers to enamine nucleophiles. A facile synthesis of substituted pyridines and ring annulated derivatives

Oxazolidines substituted at C-2 with -CH2-EW(-CO-, etc.) and capable of existing as ring-chain (enamine) tautomers react with cyclic, acyclic and heterocyclic enamine derivatives in a 1:1 stoi-chiometric manner to provide a versatile synthesis of substituted pyridines and their ring annulated derivatives.

Bronchodilating pyrido?2,3-d!pyrimidine derivatives

A rapid-acting remedy for asthma having a bronchodilating action contains at least one pyrido?2,3-d!pyrimidine derivative represented by the general formula (A) or pharmaceutically acceptable salts or metal complexes thereof as an effective component: STR1 wherein R1 and R2 are the same or different and each of R1 and R2 is hydrogen, alkyl or benzyl; R3 is hydrogen, hydroxyl, dialkylaminomethyleneamino or --NH--X; X is hydrogen, alkyl, alkenyl, hydroxyl, amino, hydroxyalkyl, benzyl or acyl; R4 is hydrogen, alkyl, halogen, nitro, amino, hydroxyl, benzyloxy, cyano, carboxyl, alkoxycarbonyl, alkoxysulfonyl, aminosulfonyl, dialkylaminosulfonyl or sulfo; and R5 is hydrogen, alkyl or amino. The rapid-acting remedy for bronchial asthma is capable of relieving the symptom of laboring breath at the onset of asthma due to its excellent bronchodilating action. It can be used as a therapy not only for allergic asthma but also for various bronchial asthmas such as endogenous asthma, exogenous asthma and dust asthma.

Reactivities of 6-amino-1,3-dimethyl-5-thioformyluracil toward nucleophiles and its application to synthesis of pyrido[2,3-d]pyrimidines

The reaction of the 5-thioformyluracil 1 with phenylhydrazine and various amines readily afforded the hydrazone 3a and Schiff bases 3b-d, respectively. Further, carbanions and Wittig reagents reacted with 1 to give pyrido[2,3-d]pyrimidines 4 and 9. The co

5-substituted pyrido[2,3-d]pyrimidine-2,4-diones

The present invention relates to a novel pyrido[2,3-d]pyrimidine derivative having the formula (I): STR1 wherein each of R1 and R2, which may be the same or different, is a lower alkyl group; and each of R3 and R4, which may be the same or different, is hydrogen, halogen, hydroxy, nitro, amino, hydroxyamino, hydrazino, azido, a lower alkenylamino group or a lower alkylamino group which may optionally have hydroxy; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

Reaction of 6-Aminouracils with Ketenethioacetals

Reaction of ketenethioacetals with 6-aminouracils (1a: R1=R2=Me, 1b: R1=Ph, R2=H) in the presence of potassium carbonate followed by cyclization unde