52329-99-4

Upstream product

• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 96-22-0 pentan-3-one 
• 10467-10-4 ethylmagnesium iodide 
• 185245-65-2 3-methylthio-3-N-piperidino-1-phenyl-2-propen-1-one 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 73830-10-1 3-ethyl-1-phenyl-1-pentyn-3-ol 
• 948913-46-0 2-(1,1-diethyl-3-phenyl-prop-2-ynyloxymethyl)oxirane 
• 760-21-4 2-ethyl-1-butene 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1168156-44-2 2-ethoxy-4,4-diethyl-6-phenyl-3,4-dihydro-2H-pyran 
• 36235-26-4 3-ethyl-1-phenyl-pent-3-en-1-one 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

Acylation of Alkenes with the Aid of AlCl3 and 2,6-Dibromopyridine

Friedel-Crafts-type acylation of alkenes with acyl chlorides has been successfully conducted with a wide substrate scope by the combined use of AlCl3 and 2,6-dibromopyridine. Trisubstituted alkenes afford allylketones or vinylketones depending on the presence or absence of hydrogen atom(s) at the β-position to the acylation site, while monosubstituted alkenes exclusively afford vinylketones.

Gold(l)-catalyzed cascade cyclization reaction: Highly regio- and diastereoselective intermodular addition of water and alcohols to epoxy alkynes

We have developed a novel access to ketal skeletons through a highly regio- and diastereoselective intermolecular addition of water and alcohols to alkynyl epoxides catalyzed by goid(l). This procedure involves a domino three-membered ring-opening, 6-exo-

Olefination of ketones using a gold(III)-catalyzed Meyer-Schuster rearrangement

An atom-economical and efficient olefination strategy for ketones is described. Ethoxyacetylide addition followed by a gold-catalyzed Meyer-Schuster rearrangement affords α,β-unsaturated esters, generally in excellent overall yield from the starting ketones. The alkynophilicity of Au3+ promotes an interaction with the electron-rich acetylenes that catalyzes the Meyer-Schuster rearrangement selectively over other conceivable pathways.

One pot synthesis of α,β-unsaturated ketones from the Mukaiyama aldol condensation

Satisfactory yields of α,β-unsaturated ketones are obtained from two trimethylsilylenol ethers and a variety of aldehydes and ketones in a one pot modified Mukaiyama aldol procedure using triethylamine and trifluoroacetic anhydride.