52333-87-6

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2-(4-methylphenyl)[1,3]oxazolo[4,5-b]pyridine is used as a research compound for its potential therapeutic effects. It is being studied for its biological activity related to the central nervous system and its potential as a treatment for various neurological disorders.
Used in Organic Synthesis and Material Science:
2-(4-methylphenyl)[1,3]oxazolo[4,5-b]pyridine may also have applications in the field of organic synthesis and material science, although further research is needed to fully understand its potential uses and effects in these areas.

Upstream product

• 52334-57-3 N¹-(3-hydroxy-2-pyridyl)-4-methylbenzamide 
• 624-31-7 4-tolyl iodide 
• 273-97-2 oxazolo<4,5-b>pyridine 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 99-94-5 p-Toluic acid 
• 7559-36-6 4-methyl-β-nitrostyrene 

Relevant academic research and scientific papers

Molecular modeling, density functional theory, ADME prediction and antimicrobial activity studies of 2-(substituted)oxazolo[4,5-: B] pyridine derivatives

In this study, the antimicrobial activities of previously synthesized 2-(substituted)oxazolo[4,5-b]pyridine derivatives toward six bacteria strains and twelve related drug-resistant isolates, and one fungus strain and two related drug-resistant isolates w

Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

In vitro and in silico evaluation of 2-(substituted phenyl) oxazolo[4,5-b]pyridine derivatives as potential antibacterial agents

Increasing resistance to antibiotics is a major problem worldwide and stimulates the development of new bacterial inhibitors. Series of oxazolo[4,5-b]pyridine synthesized in our lab was examined to screen them as potential antimicrobial agents. The antimi

Acid-Catalyzed, Silica-Supported, One-Pot Benzoylation Route to Synthesize 2-(Substituted Phenyl)oxazolo[4,5-b]pyridines under Ambient Conditions

The present paper describes a silica-supported, perchloric-acid-catalyzed, efficient protocol for the synthesis of 2-(phenyl)oxazolo[4,5-b]pyridine derivatives. This strategy has high conversion, simple workup procedures, ambient conditions, short reactio

A rapid method for the preparation of 2-substituted oxazolo[4,5-b]pyridines using microwave-assisted direct condensation reactions

The condensation reaction of 2-amino-3-hydroxypyridine with different carboxylic acids by microwave-assisted heating is a fast method for producing libraries based on fused 2-substituted oxazolo[4,5-b]pyridines in moderate to good yields.

TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY

There are disclosed compound of Formula (1): A1, A2, A3 and A4 which may be the same or different, represent N or CR1, X is a divalent group selected from O, S(O)n, C=W, NR4, NC(=O)R5 and CR6R7, W is O, S, NR20, Y is N or CR8, one of R4, R5, R6, R8, R9 and NR20 represents - L -R3, in which L is a single bond or a linker group, additionally, R1, R3 - R9, which may be the same or different, independently represent hydrogen or a substituent and R20 represents hydrogen, hydroxyl, alkyl optionally substituted by aryl, alkoxy optionally substituted by aryl, aryl, CN, optionally substituted alkoxy, optionally substituted aryloxy, optionally substitute alkanoyl, optionally substituted aroyl, NO2, NR30R31, in which R30 and R31, which may be the same or different, represent hydrogen, optionally substituted alkyl or optionally substituted aryl; additionally, one of R30 and R31 may represent optionally substituted alkanoyl or optionally substituted aroyl, n represents an integer from 0 to 2, in addition, when an adjacent pair of A1 - A4 each represent CR1, then the adjacent carbon atoms, together with their substituents may form a ring B, when X is CR6R7, R6 and R7, together with the carbon atom to which they are attached may form a ring C, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia.

Unprecedentedly mild direct Pd-catalyzed arylation of oxazolo[4,5-b] pyridine

Pd-catalyzed C-2 arylation of oxazolo[4,5-b]pyridine proceeds efficiently at 30°C and tolerates a variety of aryl halides, including derivatized amino acids for which no racemization was observed during the reaction. Experimental evidence for facile depro

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.