273-97-2

Basic information

• Product Name: Oxazolo[4,5-b]pyridine
• Synonyms: Oxazolo[4,5-b]pyridine
• CAS NO: 273-97-2
• Molecular Formula: C₆H₄N₂O
• Molecular Weight: 120.10876
• Mol File: 273-97-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 69-72 °C
• Boiling Point: 199.2±13.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.27±0.40(Predicted)
• CAS DataBase Reference: Oxazolo[4,5-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazolo[4,5-b]pyridine(273-97-2)
• EPA Substance Registry System: Oxazolo[4,5-b]pyridine(273-97-2)

Safety Data

• Hazardous Substances Data: 273-97-2(Hazardous Substances Data)

Usage

General Description

Oxazolo[4,5-b]pyridine is a chemical compound that belongs to the oxazole class of compounds. It is a heterocyclic compound which contains both oxygen and nitrogen atoms in its ring structure. Oxazolo[4,5-b]pyridine has potential pharmaceutical applications and has been studied for its potential as an anti-cancer agent and in the treatment of neurological disorders. Oxazolo[4,5-b]pyridine has also been investigated for its antimicrobial and anti-inflammatory properties. Its chemical structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 1447734-44-2 C₂₇H₁₅F₃N₄O₃ 
• 1276038-50-6 C₂₈H₁₄F₆N₄O₃ 
• 1189168-00-0 8-(benzyloxy)-5-chloro-7-[1,3]oxazolo[4,5-b]pyridin-2-ylquinoline 
• 95331-56-9 4-[1,3]oxazolo[4,5-b]pyridin-2-ylaniline 
• 52333-46-7 2-(4-methoxyphenyl)[1,3]oxazolo[4,5-b]pyridine 
• 52333-87-6 2-(4-methylphenyl)[1,3]oxazolo[4,5-b]pyridine 
• 52333-45-6 2-(4-chlorophenyl)[1,3]oxazolo[4,5-b]pyridine 
• 52333-44-5 2-phenyl[1,3]oxazolo[4,5-b]pyridine 
• 52333-71-8 2-pyridyl-2-yl[1,3]oxazolo[4,5-b]pyridine 

Relevant articles and documents

COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF

PROBLEM TO BE SOLVED: To provide a compound having a ZNF143 inhibitory activity as well as to provide a ZNF143 inhibitory agent and pharmaceutical composition containing the same. SOLUTION: Provided is a compound represented by formula (I) or a salt thereof as well as a ZNF143 inhibitory agent containing the same and a pharmaceutical composition having the same as an active ingredient. A-B-C-D (I)[A is H, a methyl group, a naphthyl group, a phenyl group or a nitrogen-containing heterocyclic ring; B is as shown below, and C is an amide bond or a heteroaromatic ring containing N and O; D is a substituted/unsubstituted phenyl group or a monocyclic heteroaromatic ring containing N or S; and C and D are both fused heterocyclic ring or the like optionally having a substituent group.]. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT

1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines

A simple and highly efficient method for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines is described. Condensation of orthoesters with o-substituted anilines or 2-amino-3-hydroxypyridine was performed in the presence of catalytic amounts of commercially available, inexpensive, and moisture-stable 1,3-dibromo-5,5-dimethylhydantoin under solvent-free conditions. The corresponding heterocycles were obtained in good to excellent yields. The main advantages of the present procedure are mild reaction conditions, short reaction times, high yields of products, easy work-up, and absence of solvent. Graphical abstract: [Figure not available: see fulltext.]

Mild and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines catalyzed by Bi(III) salts under solvent-free conditions

A series of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was efficiently synthesized from the reactions of o-aminophenols, o-aminothiophenol, o-phenylenediamines, and 2-amino-3- hydroxypyridine with orthoesters in the presence of catalytic amounts of Bi(III) salts, such as Bi(TFA)3, Bi(OTf)3, and BiOClO4 ? xH2O under solvent-free conditions. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of relatively non-toxic catalysts. Springer-Verlag 2007.