52334-01-7

Basic information

• Product Name: Benzonitrile, 4-oxazolo[5,4-b]pyridin-2-yl-
• CAS NO: 52334-01-7
• Molecular Formula: C13H7N3O
• Molecular Weight: 221.218
• Mol File: 52334-01-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-oxazolo[5,4-b]pyridin-2-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-oxazolo[5,4-b]pyridin-2-yl-(52334-01-7)
• EPA Substance Registry System: Benzonitrile, 4-oxazolo[5,4-b]pyridin-2-yl-(52334-01-7)

Safety Data

• Hazardous Substances Data: 52334-01-7(Hazardous Substances Data)

Upstream product

• 52334-69-7 3-(4-chloro-benzoylamino)-1H-pyridin-2-one 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 105-07-7 4-cyanobenzaldehyde 
• 33630-99-8 2-hydroxy-3-aminopyridine 
• 126921-78-6 3-(4-cyano-benzoylamino)-2-chloropyridine 
• 544-92-3 copper(I) cyanide 
• 52334-06-2 2-(4-chloro-phenyl)oxazolo<5,4-b>pyridine 
• 6298-19-7 2-chloro-3-aminopyridine 

Relevant articles and documents

A convenient synthesis of substituted oxazolo-[5,4-b]pyridines using lead tetraacetate as oxidative cyclizing agent

Various substituted oxazolo[5,4-b]pyridines 5a-d have been synthesized by condensation of appropriate hydroxyaminopyridines and aldehydes followed by oxidative cyclization of the resulting Schiff's bases with lead tetraacetate. This method has been extended to the synthesis of the DNA minor groove binding ligands 5e and 5f related to Hoechst 33258 1.

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.