52334-06-2

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 6298-19-7 2-chloro-3-aminopyridine 
• 91813-33-1 N-(2-chloro-3-pyridinyl)-4-chlorophenylamide 
• 52334-69-7 3-(4-chloro-benzoylamino)-1H-pyridin-2-one 

Downstream Products

• 52334-01-7 2-(4-cyano-phenyl)oxazolo<5,4-b>pyridine 

Relevant academic research and scientific papers

A general and efficient synthesis of 2-substituted oxazolopyridines

Starting from commercially available halonitropyridines and haloaminopyridines, 2-substituted-oxazolo[5,4-b]pyridines, and 2-aryl-oxazolo[4,5-b]pyridines were synthesized in good yields by using a Cu(I)-mediated cyclization of halopyridylamides as a key step. Georg Thieme Verlag Stuttgart.

Process for the synthesis of oxazolopyridine compounds

Process for the synthesis of compounds of formula (I): STR1 their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; R1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; 0≤m≤2; R2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group STR2 such that: R3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, 0≤n≤5 employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

A New Convenient Synthesis of 2-Aryl- and 2-Heteroaryloxazolopyridines

Several 2-aryl- and 2-heteroaryloxazolopyridines were synthesized in high yields from 3-(arylcarbonylamino)-2-chloropyridines by heating in the presence of trimethylsilylpolyphosphate ester.

2-ARYL-OXAZOLO- AND THIAZOLOPYRIDINES. SYNTHESIS VIA CYCLIZATION OF N-(2-CHLORO-3-PYRIDINYL)ARYLAMIDES AND THIOAMIDES

Chloropyridinylenamides can by easily converted into oxazolo- and thiazolo pyridines by treatment with polyphosphoric acid and Lawesson reagent respectively.

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.