52340-20-2

Basic information

• Product Name: (S)-2-Methylaziridine
• Synonyms: (S)-2-METHYL AZIRIDINE;Aziridine, 2-methyl-, (2S)-
• CAS NO: 52340-20-2
• Molecular Formula: C₃H₇N
• Molecular Weight: 57.09
• Mol File: 52340-20-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 66.5 °C at 760 mmHg
• Appearance: /
• Density: 0.824g/cm³
• Refractive Index: 1.413
• PKA: 8.21±0.40(Predicted)
• CAS DataBase Reference: (S)-2-Methylaziridine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Methylaziridine(52340-20-2)
• EPA Substance Registry System: (S)-2-Methylaziridine(52340-20-2)

Safety Data

• Hazard Codes: T
• Statements: 11-34-41-37/38-25
• Safety Statements: 16-26-36-45-39
• RIDADR: 2733
• Hazardous Substances Data: 52340-20-2(Hazardous Substances Data)

Usage

General Description

(S)-2-Methylaziridine, also known as 2-methyl-2-aziridine, is a chemical compound with the molecular formula C4H9N. It is a colorless liquid with a strong ammonia-like odor and is highly flammable. (S)-2-Methylaziridine is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It is a versatile building block for the preparation of chiral amines and heterocyclic compounds. Additionally, (S)-2-Methylaziridine has been studied for its potential use in asymmetric synthesis and as a reagent for the modification of natural products. Due to its reactivity and potential health hazards, it should be handled and stored with care and in accordance with appropriate safety protocols.

InChI:InChI=1/C3H7N/c1-3-2-4-3/h3-4H,2H2,1H3/t3-/m1/s1

Upstream product

• 114080-83-0 2-ammoniopropyl sulfate 
• 126301-21-1 (S)-2-aminopropanol methanesulfonate hydrochloride 
• 119461-40-4 S-(+)-2-methyl-N-p-tosylaziridine 
• 946088-68-2 benzyl 2-methylaziridine-1-carboxylate 
• 75-55-8 2-Methylaziridine 
• 2799-16-8 (2R)-hydroxypropylamine 
• 2749-11-3 (S)-Alaninol 

Downstream Products

• 110481-01-1 (2S,9S)-4,7-diphenyl-4,7-diphosphodecane-2,9-diamine 
• 189098-77-9 (S)-3,3,3-Trifluoro-2-methoxy-1-((S)-2-methyl-aziridin-1-yl)-2-phenyl-propan-1-one 
• 7297-06-5 (S)-2-aminopropane-1-sulfonic acid 
• 946088-68-2 benzyl 2-methylaziridine-1-carboxylate 
• 1202556-45-3 C₁₉H₂₁NO₃S 
• 1430334-89-6 C₁₈H₁₇NO₃ 
• 1430334-91-0 C₁₂H₁₃NO₃ 
• 122673-70-5 (S)-1-methyl-2-phenylsylfanylethylamine 

Relevant articles and documents

Synthesis and evaluation of biological activities of aziridine derivatives of urea and thiourea

In the present paper, we report the synthesis and evaluation of in vitro antimicrobial activities of aziridine-thiourea derivatives. A series of aziridines in reaction with isocyanates and isothiocyanates to obtain urea and thiourea derivatives were used.

Synthesis of novel N-protected β3-amino nitriles: study of their hydrolysis involving a nitrilase-catalyzed step

Several commercially available nitrilases were investigated with regard to their potential to hydrolyze N-protected β3-amino nitriles into their corresponding N-protected β3-amino acids. The biotransformations were obtained in different proportions depending on the nitrilase involved. The best hydrolysis results were achieved for the N-Cbz-β3-amino nitrile from l-alanine using the NIT-107, in a phosphate buffer at 0.05 M. However, no biotransformation into the corresponding acids was observed for the N-sulfonylamide β3-amino nitriles. Two simple and efficient procedures to prepare the β3-amino nitriles from their analogous α-amino acids are described. Thirty four new substances were synthesized and characterized over the course of this work.

Efficient Optical Resolution of Aziridines with Optically active host compounds

Some aziridines are resolved efficiently by complexation with optically active host compounds which were derived from tartaric acid.