52364-31-5

Usage

Uses

Used in Plastics and Textile Industry:
Phosphonic acid, (hydroxymethyl)-, diphenyl ester is used as a flame retardant for enhancing the fire safety of plastics and textiles. It achieves this by releasing chemicals that inhibit the combustion process, thereby preventing the spread of fire.
Used in Organic Synthesis:
In the field of organic chemistry, Phosphonic acid, (hydroxymethyl)-, diphenyl ester is employed as a catalyst to facilitate various chemical reactions, improving the efficiency and selectivity of the synthesis processes.
Used in Polymer Industry:
Phosphonic acid, (hydroxymethyl)-, diphenyl ester is used as a stabilizer for polymers, helping to maintain their structural integrity and performance over time, particularly under conditions of stress or exposure to environmental factors.
Used in Agricultural Industry:
Phosphonic acid, (hydroxymethyl)-, diphenyl ester has potential applications in agriculture as a herbicide and pesticide, where it can help control the growth of unwanted plants and protect crops from pests. However, its use in this context requires careful consideration of potential environmental and health impacts.
It is important to handle Phosphonic acid, (hydroxymethyl)-, diphenyl ester with care, as it may have harmful effects on human health and the environment if not managed properly.

Upstream product

• 80141-24-8 Phosphorigsaeure-diphenyl-trimethylsilylester 
• 4712-55-4 diphenyl hydrogen phosphite 
• 50-00-0 formaldehyd 
• 102-10-3 diphenyl phosphite 
• 3577-87-5 diphenyl methyl phosphite 

Downstream Products

• 1234080-98-8 diphenyl [5-(R)-(6-methoxypurin-9-yl)-4-(R)-fluoro-3-(R)-iodo-tetrahydrofuran-2(R)-yloxymethyl]phosphonic acid 
• 115989-09-8 dibenzyl trifluoromethane sulfonic hydroxymethyl phosphonate 

Relevant academic research and scientific papers

Synthesis of Rovafovir Etalafenamide (Part III): Evolution of the Synthetic Process to the Phosphonamidate Fragment

Phosphonamidate 1 is a key fragment in the assembly of rovafovir etalafenamide, a novel nucleotide reverse transcriptase inhibitor under development at Gilead Sciences for the treatment of HIV infection. An early manufacturing route, relying on simulated moving bed (SMB) chromatography for the separation of phosphorus diastereomers, was executed on scale to produce multiple batches of 1. However, developing alternative synthetic conditions became desirable in consideration of the high production cost, long lead time, and high process mass intensity (PMI) associated with SMB. Several strategies to improve these factors are described herein, including epimerization and recycling of the undesired (R)-phosphorus diastereomer, design of stereoselective approaches to establish the desired (S)-configuration at phosphorus, and identification of conditions or derivatives to allow for selective crystallization. Ultimately, a second-generation route to 1 was developed and demonstrated on scale. The new route achieves the separation of phosphorus diastereomers by means of selective crystallization, does not require SMB, and offers lower PMI, cost, and lead time.

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

GS-9148 [(5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl)phosph onic acid] 4 is a novel nucleoside phosphonate HIV-1 reverse transcriptase (RT) inhibitor with a unique resistance profile toward N(t)RTI resistance mutations. To effectively

Phosphorus-containing phenolic, thiophenolic or aminophenyl flame-retardant hardener, and epoxy resins cured thereby

A hardener for an epoxy resin comprises a phenolic, thiophenolic, aminophenyl, tris-phenolic, tris-thiophenolic, tris-aminophenyl, tetrakis-phenolic, tetrakis-thiophenolic, or tetrakis-aminophenyl compounds; or phenol-formaldehyde or phenol-formaldehyde/melamine-formaldehyde resins wherein the phenyl rings are substituted with at least one of the structures wherein R1and R2independently are H, C1-C18alkyl, C6-C18aryl, C6-C18substituted aryl, C6-C18aryl methylene, or C6-C18substituted aryl methylene; X is O, S or NH and Ar is wherein R is C1-C4alkyl and n=0-5.

(Phosphonomethyl)trifluoromethyl sulfonates

The compound (phosphonomethyl)perfluoroalkyl sulfonate can be represented by the formula STR1 wherein n is from 0 to 7 and R and R1 are independently selected from the group consisting of hydrogen, 2-cyanoethyl, monovalent hydrocarbons containing from 1 to 18 carbons, monovalent hydrocarbonoxyhydrocarbons containing from 1 to 18 carbons, halogenated monovalent hydrocarbons containing from 1 to 18 carbons and from 1 to 3 halogens, halogenated monovalent hydrocarbonoxyhydrocarbons containing from 1 to 18 carbons and from 1 to 3 halogens. The compound is useful as an intermediate to prepare amino-phosphorous compounds such as N-phosphonomethylglycine.