52370-40-8

Basic information

• Product Name: O-[(2,4-Dichlorophenyl)methyl]hydroxylamine
• Synonyms: 2,4-Dichlorobenzylhydroxylamine;O-[(2,4-Dichlorophenyl)methyl]hydroxylamine;2,4-Dichloro-benzylhydroxylaMine hydrochloride;O-(2,4-Dichlorobenzyl)hydroxylaMine;Hydroxylamine, O-[(2,4-dichlorophenyl)methyl]-;2,4-d2ichloro-benzyloxylaminehydrochloride
• CAS NO: 52370-40-8
• Molecular Formula: C₇H₇Cl₂NO
• Molecular Weight: 192.04258
• EINECS: 5237-040-8
• Mol File: 52370-40-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.374
• Storage Temp.: 2-8°C
• CAS DataBase Reference: O-[(2,4-Dichlorophenyl)methyl]hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-[(2,4-Dichlorophenyl)methyl]hydroxylamine(52370-40-8)
• EPA Substance Registry System: O-[(2,4-Dichlorophenyl)methyl]hydroxylamine(52370-40-8)

Safety Data

• Hazardous Substances Data: 52370-40-8(Hazardous Substances Data)

Usage

General Description

O-[(2,4-Dichlorophenyl)methyl]hydroxylamine is a chemical compound with the formula C7H8Cl2NO. It is a derivative of hydroxylamine and is used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. O-[(2,4-Dichlorophenyl)methyl]hydroxylamine is a white solid that is soluble in polar organic solvents and water. O-[(2,4-Dichlorophenyl)methyl]hydroxylamine has potential applications in various industries, including pharmaceuticals, agriculture, and chemical manufacturing. Due to its functional groups, it can participate in a variety of chemical reactions, making it a versatile compound with a range of potential uses.

Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 1777-82-8 (2,4-dichlorophenyl)methanol 
• 339106-00-2 2-(2,4-dichlorobenzyloxy)isoindole-1,3-dione 
• 20443-99-6 2,4-dichlorobenzyl bromide 

Downstream Products

• 107922-31-6 N-<3,4-Dichlor-benzyl>-N'-<2,4-dichlor-benzyloxy>-thioharnstoff 
• 41970-84-7 3-[(2,4-dichloro-benzyloxyimino)-methyl]-rifamycin 
• 100873-19-6 O-<2.4-Dichlor-benzyl>-2.4-dichlor-benzaldoxim 
• 51572-93-1 O-(2,4-dichlorobenzyl)hydroxylamine hydrochloride 
• 1299491-52-3 4,5-dibromo-1H-pyrrole-2-carboxylic acid (2,4-dichlorobenzyloxy)amide 

Relevant articles and documents

N-(benzyloxy)-2-chloronicotinamide compound as well as preparation method and application thereof

The invention belongs to the technical field of chemical synthesis and medicine application, and particularly relates to preparation and application of an N-(benzyloxy)-2-chloronicotinamide compound. The preparation method comprises the following steps: reacting phthalic anhydride with hydroxylamine, then reacting with triethylamine for acidification to prepare N-hydroxyphthalimide, then carrying out substitution and hydrazinolysis, and finally reacting with dichloronicotinoyl chloride to prepare the N-(benzyloxy)-2-chloronicotinamide compound. The preparation method disclosed by the invention is simple and convenient to operate, the structure of the obtained product is confirmed by a nuclear magnetic hydrogen spectrum, herbicidal activity tests are carried out on the obtained 15 target products, and results show that all target compounds have an obvious inhibition effect on the seeds of the Agrostis matsumurae under the concentration of 1mM, and the inhibition effect reaches 100%; and along with the decrease of the concentration, even if the concentration reaches 100 [mu] M, the target compound can still show good herbicidal activity.

Design, synthesis, molecular docking and biological evaluation of novel coumarin-oxime ether derivatives as COX-2 inhibitors

Coumarin-oxime ether derivatives (14-25) were synthesized by an efficient and straight forward procedure from the reaction of 3-acetyl coumarin (1) and o-substituted benzyl hydroxyl amines (2-13) in pyridinium p-toluenesulfonate/dichloromethane (PPTS/DCM)

Design, synthesis and antifungal activities of novel pyrrole alkaloid analogs

A series of novel analogs of pyrrole alkaloid were designed and synthesized by a facile method and their structures were characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry (HRMS). The structure of compound 2a was identified by 2D NMR including heteronuclear multiple-quantum coherence (HMQC), heteronuclear multiple-bond correlation (HMBC) and H-H correlation spectrometry (H-H COSY) spectra. Their antifungal activities against five fungi were evaluated, and the results indicated that some of the title compounds showed moderate fungicidal activities in vitro against Alternaria solani, Cercospora arachidicola, Fusarium omysporum, Gibberella zeae and Physalospora piricola at the dosage of 50 μg mL -1. Compound 2a and 3a exhibited good activities against P. piricola at low dosage.