52389-41-0Relevant academic research and scientific papers
Synthesis of feruloyl-myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and Esptein-Barr virus activation
Hosoda, Asao,Nomura, Eisaku,Murakami, Akira,Koshimizu, Koichi,Ohigashi, Hajime,Mizuno, Kazuhiko,Taniguchi, Hisaji
, p. 1855 - 1863 (2002)
We prepared 14 feruloyl-myo-inositol derivatives, and evaluated the relationships between their stereostructure and inhibitory activity toward the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced superoxide (O2-) generation. And further, their suppressive effect on the TPA-induced Epstein-Barr virus (EBV) activation was examined in order to estimate their anti-carcinogenic potentials. Among the derivatives tested, 1,6-O-bis[3-(4′-hydroxy-3′-methoxyphenyl)-2-propenoyl]-myo- inositol (6b) showed an excellent suppressive activity on the O2- generation at a concentration of 20 μM. For the suppressive effects on the EBV activation, 2,4,6-O-tris[3-(4′-hydroxy-3′-methoxyphenyl)-2-propenoyl]-myo- inositol 1,3,5-orthoformate (9b) showed the highest activity at a concentration of 100 μM among the derivatives tested. These results suggest that the inhibitory potencies of feruloyl-myo-inositol derivatives depend on the stereostructure of molecules rather than the hydrophobicity of molecules.
COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS
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, (2009/10/22)
One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyIoidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
Design and synthesis of biotinylated inositol phosphates relevant to the biotin-avidin techniques
Anraku, Kensaku,Inoue, Teruhiko,Sugimoto, Kenji,Morii, Takashi,Mori, Yasuo,Okamoto, Yoshinari,Otsuka, Masami
experimental part, p. 1822 - 1830 (2008/10/09)
Six bifunctional molecules containing biotin and various inositol phosphates were synthesized. These compounds were designed on the basis of X-ray structures of the complexes of d-myo-inositol 1,4,5-triphosphates (IP 3) and phospholipase C δ pleckstrin homology domain (PLCδ PH) considering the application to the biotin-avidin techniques. The building blocks of the inositol moiety were synthesized starting with optically resolved myo-inositol derivatives and assembled to the biotin linker through a phosphate linkage. The Royal Society of Chemistry.
Flexible stereo- and regioselective synthesis of myo-inositol phosphates (Part 2): Via nonsymmetrical conduritol B derivatives
Podeschwa, Michael A. L.,Plettenburg, Oliver,Altenbach, Hans-Josef
, p. 3116 - 3127 (2007/10/03)
A practical route is described for the preparation of myo-inositol phosphates. Optically pure compounds can be prepared, in both forms, from p-benzoquinone by enzymatic resolution of a diacetoxyconduritol key intermediate. Monosubstituted inositol derivat
Novel Discotic Liquid Crystalline, Polar Monothioscyllitol Derivatives
Kohne, Bernd,Marquardt, Peer,Praefcke, Klaus,Psaras, Panicos,Stephan, Werner
, p. 628 - 642 (2007/10/02)
On the basis of an improved synthesis of the 1,3,4,5,6-pentaacetate of myo-inositol, now available in only one step from that cyclitol in yields up to 90percent, we prepared various derivatives 3-5 of 1-deoxy-1-mercapto-scyllo-inositol (monothioscyllitol) via the mesylate 1a or the trifluoromesylate 1b, respectively.The non-centrosymmetric disc-shaped thioethers 3a-h as well as their S,S-dioxides 4a-h and the S-oxide 5f exhibit thermotropic discotic mesophases over wide temperature ranges.The thermomesomorphism of these new sulfur compounds has been studied by optical microscopy and by differential scanning calorimetry.The pentabutyrates 3a and 4a as well as the dimesomorphic pentapentanoate 3b exhibit a probably new type of discophase Dx whereas all other monothioscyllitol derivatives with longer alkyl chains show the Dho-phase over wide temperature ranges.Of some selected new thioethers 3, sulfones 4, and of the sulfoxide 5f the dipole moments have been measured which are highest with the cyano derivatives 3g and 4g at about 5 or above 6 D, respectively.These values characterize them as the strongest polar discogens studied so far.The presented monothioscyllitol derivatives 3, 4 and 5 do not only increase the number of rarely known polar discogens, but also show that non-centrosymmetric and polar discotic liquid crystals with a small, alimonocyclic, saturated "core" now can be prepared easily.Their permanent electric dipole moments could give rise to interesting magnetic or electric field effects. - Inositols, Cyclohexane Derivatives, Discogenes, Discophases, Dipole Moments
INVESTIGATIONS IN THE FIELD OF ASYMMETRICALLY SUBSTITUTED MYOINOSITOL DERIVATIVES. XXX. REACTION OF 2,3-DIHYDROPYRAN WITH TETRASUBSTITUTED DERIVATIVES OF MYOINOSITOL
Stepanov, A. E.,Sibrikov, Yu. I.,Shvets, V. I.
, p. 1946 - 1950 (2007/10/02)
In the reaction of 2,3-dihydropyran with 1(3),4(6),5,6(4)-tetra-O-benzyl- and 1(3),4(6),5,6(4)-tetra-O-acetyl-sn-myoinositols the corresponding mono- and ditetrahydropyranyl ethers are formed.
