52396-77-7

Upstream product

• 52396-76-6 1,1,1-trichloro-3-thiazol-2-yl-propan-2-ol 
• 10200-59-6 Thiazole-2-carbaldehyde 
• 141-82-2 malonic acid 

Downstream Products

• 98025-45-7 2-[1-(hydroxyimino)ethyl]-thiazole 
• 52396-78-8 3-amino-3-thiazol-2-yl-propionic acid 
• 144163-65-5 3-(thiazol-2-yl)propanoic acid 
• 2643-75-6 (+)-β-(2-Thiazolyl)-β-alanin 
• 64107-58-0 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-thiazol-2-ylmethyl-1H-pyrimidin-4-one; hydrochloride 
• 1007-43-8 L-β-(2-Thiazolyl)-β-alanin 

Relevant academic research and scientific papers

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.

Isocytosine H2-receptor histamine antagonists II. Synthesis and evaluation of biological activity at histamine H1- and H2-receptors of 5-(heterocyclyl)methylisocytosines

A series of 2--4-pyrimidones was synthesized based on oxmetidine 2, in which the methylenedioxyphenyl group of 2 was replaced by a heterocyclic ring.Good H2-receptor antagonist activity was retained over a range of basic and neutral heterocyclic substituents.Replacement of the 5-methyl-4-imidazolyl ring in selected compounds with 2-thiazolyl and, particularly, 3-bromo-2-pyridyl rings gave a series of compounds which have both H1- and H2-receptor histamine antagonist activities.Some structure-activity and structure-toxicity correlations are discussed.Compound 6d, 2--5-(6-methylpyrid-3-yl)-4-pyrimidone, has the most favourable combination of properties for H2-antagonism and has been evaluated further as an anti-secretory agent.