524035-97-0

Usage

Chemical compound

A derivative of indole, which is an organic compound that contains a benzene ring fused to a pyrrole ring.

Structure

Contains both a benzyl and a thioacetic acid group, which are organic functional groups that contribute to its chemical properties.

Applications

Commonly used in research and pharmaceutical applications due to its potential therapeutic properties.

Antidiabetic properties

Has been studied for its ability to help regulate blood sugar levels and improve insulin sensitivity.

Anti-inflammatory properties

Exhibits potential to reduce inflammation, which can be beneficial in treating conditions characterized by chronic inflammation.

Anticancer properties

Shows promise as a potential drug candidate for various types of cancer due to its ability to inhibit cancer cell growth and proliferation.

Neuroprotective effects

Demonstrates potential to protect neurons and support brain health, which can be useful in the treatment of neurodegenerative diseases.

Medicinal chemistry

1-Benzylindole-3-thioacetic acid's diverse range of potential therapeutic properties makes it an interesting compound for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C17H15NO2S/c19-17(20)12-21-16-11-18(10-13-6-2-1-3-7-13)15-9-5-4-8-14(15)16/h1-9,11H,10,12H2,(H,19,20)

Upstream product

• 3377-71-7 N-benzylindole 
• 79-11-8 chloroacetic acid 
• 120-72-9 indole 
• 1049779-48-7 C₁₆H₁₅N₃S*HI 

Relevant academic research and scientific papers

Synthesis of Immunoactive Tris(2-hydroxyethyl)ammonium 1-R-Indol-3-ylsulfanyl(sulfonyl)acetates

Difficultly accessible 1-R-indol-3-ylsulfanyl(sulfonyl)acetic acids 1-R-IndYCH2CO2H (R = H, Me, Bn; Y = S, SO2) 1a–Id were prepared. Their reaction with tris(2-hydroxyethyl)amine yielded tris(2-hydroxyethyl) ammonium 1-R-i

Directed synthesis and immunoactive properties of (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)alkanecarboxylic acids

A general method for the synthesis of 1-alkyl(allyl)(benzyl)-substituted (indol-3-yl)-sulfanylalkanecarboxylic acids and hexane-1,6-diyl(1,4- phenylenemethylene)bisindol-3-ylsulfanylalkanecarboxylic acids from the corresponding N-substituted indoles and bisindoles, thiourea, iodine, and halogencarboxylic acids was developed. The oxidation of substituted (indol-3-yl)sulfanylalkanecarboxylic acids for the first time afforded their analogs containing the sulfonyl group. New (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)-alkanecarboxylic acids, which are structural analogs of highly active immunomodulators of indacetamin and VILIM, were synthesized. Among the studied (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanylacetic and -sulfonylalkanecarboxylic acids, the compounds exhibiting high dose-dependent antiproliferative activity by the ability to affect the spontaneous and mitogen-stimulated splenocyte proliferation of mice in vitro were found.

Synthesis of (3-indolylsulfanyl)alkanecarboxylic acids

A method was developed for preparation of (3-indolylsulfanyl)alkanecarboxylic acids from 1H-, 1-methyl(benzyl)-, 2-methylindoles, thiourea, iodine, and halocarboxylic acids.