1049779-48-7

Basic information

• Product Name: 1-BENZYL-1H-INDOL-3-YL IMIDOTHIOCARBAMATE HYDROIODIDE
• Synonyms: 1-BENZYL-1H-INDOL-3-YL IMIDOTHIOCARBAMATE HYDROIODIDE;IFLAB-BB F1386-0159;1-benzyl-1H-indol-3-yl carbamimidothioate hydroiodide
• CAS NO: 1049779-48-7
• Molecular Formula: C₁₆H₁₅N₃S*HI
• Molecular Weight: 409.29
• Mol File: 1049779-48-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-1H-INDOL-3-YL IMIDOTHIOCARBAMATE HYDROIODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-1H-INDOL-3-YL IMIDOTHIOCARBAMATE HYDROIODIDE(1049779-48-7)
• EPA Substance Registry System: 1-BENZYL-1H-INDOL-3-YL IMIDOTHIOCARBAMATE HYDROIODIDE(1049779-48-7)

Safety Data

• Hazardous Substances Data: 1049779-48-7(Hazardous Substances Data)

Usage

Type of compound

Chemical compound used in medicinal chemistry research.

Form

Hydroiodide salt form of the imidothiocarbamate derivative.

Potential activity

Antineoplastic activity.

Possible effects on cancer cells

Inhibition of proliferation and induction of apoptosis.

Potential use

Anticancer drug development.

Chemical structure

Benzyl group attached to an indol-3-yl imidothiocarbamate.

Unique properties and pharmacological effects

Determined by the chemical structure.

Further research needs

Studies required to understand mechanisms of action and potential therapeutic applications.

Upstream product

• 120-72-9 indole 
• 3377-71-7 N-benzylindole 
• 17356-08-0 thiourea 

Downstream Products

• 1312670-75-9 [(1-benzylindol-3-yl)sulfanyl]propionic acid 
• 728041-68-7 2-hydroxy-N,N-bis(2-hydroxyethyl)ethaneammonium [(1-benzylindol-3-yl)sulfanyl]acetate 
• 1237036-51-9 [(1-benzylindol-3-yl)sulfonyl]acetic acid 
• 1312670-87-3 2-[(1-benzylindol-3-yl)sulfonyl]propionic acid 
• 1312670-88-4 2-[(1-benzylindol-3-yl)sulfonyl]butanoic acid 
• 1312670-89-5 2-[(1-benzylindol-3-yl)sulfonyl]-2-methylpropionic acid 
• 1312670-94-2 2-hydroxy-N-(2-hydroxyethyl)-N-methylethaneammonium [(1-benzylindol-3-yl)sulfanyl]acetate 
• 1312670-95-3 2-hydroxy-N-(2-hydroxyethyl)-N-methylethaneammonium [(1-benzylindol-3-yl)sulfonyl]acetate 
• 1312670-96-4 2-hydroxy-N,N-dimethylethaneammonium [(1-benzylindol-3-yl)sulfonyl]acetate 
• 1312670-97-5 2-hydroxy-N,N-bis(2-hydroxyethyl)ethaneammonium [(1-benzylindol-3-yl)sulfonyl]acetate 
• 1312670-98-6 2-hydroxy-N,N-bis(2-hydroxyethyl)ethaneammonium 2-[(1-benzylindol-3-yl)sulfonyl]propanoate 
• 1312670-77-1 2-[(1-benzylindol-3-yl)sulfanyl]butanoic acid 
• 1312670-78-2 2-[(1-benzylindol-3-yl)sulfanyl]-2-methylpropionic acid 
• 524035-97-0 (1-benzylindol-3-ylsulfanyl)acetic acid 

Relevant articles and documents

Directed synthesis and immunoactive properties of (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)alkanecarboxylic acids

A general method for the synthesis of 1-alkyl(allyl)(benzyl)-substituted (indol-3-yl)-sulfanylalkanecarboxylic acids and hexane-1,6-diyl(1,4- phenylenemethylene)bisindol-3-ylsulfanylalkanecarboxylic acids from the corresponding N-substituted indoles and bisindoles, thiourea, iodine, and halogencarboxylic acids was developed. The oxidation of substituted (indol-3-yl)sulfanylalkanecarboxylic acids for the first time afforded their analogs containing the sulfonyl group. New (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)-alkanecarboxylic acids, which are structural analogs of highly active immunomodulators of indacetamin and VILIM, were synthesized. Among the studied (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanylacetic and -sulfonylalkanecarboxylic acids, the compounds exhibiting high dose-dependent antiproliferative activity by the ability to affect the spontaneous and mitogen-stimulated splenocyte proliferation of mice in vitro were found.