52426-86-5Relevant academic research and scientific papers
Selective catalytic oxidation of cyclohexylbenzene to cyclohexylbenzene-1-hydroperoxide: A coproduct-free route to phenol
Arends, Isabel W.C.E,Sasidharan, Manickam,Kühnle, Adolf,Duda, Mark,Jost, Carsten,Sheldon, Roger A
, p. 9055 - 9061 (2002)
A method is described for the highly selective oxidation of cyclohexylbenzene to cyclohexylbenzene-1-hydroperoxide. In the presence of 0.5mol% N-hydroxyphthalimide (NHPI) and 2mol% of the hydroperoxide product, without solvent, a selectivity of ca. 98% to the desired product was obtained at 32% conversion. The use of NHPI increases the selectivity for initial H-abstraction from the 1-position, vs the other positions in the cyclohexyl ring, suppresses byproduct formation via transannular hydrogen abstraction and increases the overall rate of reaction.
